Investigation on the clinical significance of BNP and cTnI detections in AMI patients with non-diabetic irritable hyperglycosemia

doi:10.3969/j.issn.1673-8640.2014.01.014

Abstract

Abstract: Objective To study the roles of B-type natriuretic peptide (BNP) and cardiac troponin I (cTnI) detections in the recent prognosis evaluation of acute myocardial infarction (AMI) patients with non-diabetic irritable hyperglycosemia. Methods According to the Results of fasting blood glucose test, 122 AMI patients were enrolled and classified into 2 groups, AMI patients with non-diabetic irritable hyperglycosemia (experimental group, 68 cases) and AMI patients without non-diabetic irritable hyperglycosemia (control group, 54 cases). The BNP and cTnI levels were detected after the onsets for 24 h. The cardiac function tests were performed for all the patients 2 weeks after admission. Their echocardiographic parameters were analyzed, meanwhile the 24 h dynamic electrocardiogram detection was performed. The heart rate and the incidence of arrhythmia were recorded, and the incidences of heart failure and cardiogenic shock within the 2 weeks were observed and analyzed retrospectively. Results The experimental group showed that the cTnI level was (10.41±6.83) μg/L, BNP level was ( 1 713.6±687.03) ng/L, and heart rate was (86±12)/min, which were significantly higher than those in control group [(5.41±2.86) μg/L, (495.61±464.39) ng/L and (77±11)/min, respectively](P<0.05, P<0.01). The levels of BNP and cTnI had a positive correlation(r²=0.753, r=0.868, P<0.01). The differences on the incidence rates of malignant arrhythmia, heart failure and cardiogenic shock between experimental and control groups were statistically significant (P<0.05). In experimental group, the left ventricular ejection fraction(LVEF) was 48.83%±5.01%, and the left ventricular fractional shortening(LVFS) was 24.88%±6.53%, which were lower than those in control group (54.82%±5.29% and 30.86%±5.89%)(P<0.01). Results The BNP and cTnI levels can help for judging the severity of AMI patients with non-diabetic irritable hyperglycosemia and evaluate the recent prognosis. BNP and cTnI can be used as risk indicators for AMI patients with non-diabetic irritable hyperglycosemia.

Key words: B-type natriuretic peptide, Cardiac troponin I, Acute myocardial infarction, Hyperglycosemia

CLC Number:

R446.1

CHEN Donglian, ZENG Fanpeng, DU Zhilin, LUO Weiping, LIANG Miaozhi, YANG Ying.. Investigation on the clinical significance of BNP and cTnI detections in AMI patients with non-diabetic irritable hyperglycosemia[J]. , 2014, 29(1): 57-60.

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