Abstract:

Objective To investigate the changes and roles of N-terminal pro-B-type natriuretic peptide（NT-proBNP）,C-reactive protein（CRP） and matrix metalloproteinase 9（MMP-9） in children with Kawasaki disease（KD）. Methods A total of 107 children suspected with KD were enrolled. Among the 107 children,68 children,including 54 cases of complete Kawasaki disease（CKD） and 14 cases of incomplete Kawasaki disease（IKD）,were confirmed as KD group,and the other 39 children were enrolled as disease control group. The levels of serum NT-proBNP,CRP and MMP-9 were determined. Receiver operating characteristic（ROC） curve was used to assess the diagnostic efficiency of each index. Results Compared with disease control group,the age and sex of KD group had statistical significance（P<0.05）. The levels of serum NT-proBNP,CRP and MMP-9 had statistical significance between KD and disease control groups（P=0.000）. There was no statistical significance in NT-proBNP,CRP and MMP-9 between CKD and IKD groups（P>0.05）. ROC curve analysis showed that the areas under the curves（AUC） of NT-proBNP,CRP and MMP-9 and combined determination predictor L in the differential diagnosis of KD were 0.858,0.861,0.689 and 0.938,respectively. Conclusions The levels of serum NT-proBNP,CRP and MMP-9 are closely related with KD,which can be used in the differential diagnosis of KD.

Key words: N-terminal pro-B-type natriuretic peptide, C-reactive protein, Matrix metalloproteinase 9, Kawasaki disease