Research progress of sialic acid markers in tumor occurrence and development

doi:10.3969/j.issn.1673-8640.2020.12.025

Abstract

Abstract:

In the occurrence and development of tumors,the abnormal expression of sialyltransferase can regulate the biological characteristics of tumor cells. Abnormal sialylation can enhance the adhesion and metastasis ability of tumor cells,and can enhance tumor resistance to chemotherapy drugs. The abnormal expression of sialyltransferase is also related to the tissue and organ specificity of tumor metastasis. Sialic acid-modified glycoproteins with abnormal structures are of value in the early diagnosis and prognostic evaluation of tumors,which makes it possible to find new tumor markers. This review introduces the related mechanisms of sialylation affecting tumor occurrence and development in the recent years and the role of serum sialic acid markers in tumor diagnosis and prognosis.

Key words: Sialylation, Sialyltransferase, Tumor

CLC Number:

R446.1

BIE Lihan, FANG Meng, LU Zhicheng, GAO Chunfang. Research progress of sialic acid markers in tumor occurrence and development[J]. Laboratory Medicine, 2020, 35(12): 1304-1309.

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