Abstract:

Objective To evaluate the diagnostic roles of human neutrophil lipocalin（HNL）,procalcitonin（PCT） and tumour necrosis factor-related apoptosis-inducing ligand（TRAIL） in patients with hematological diseases. Methods A total of 120 blood culture-positive hematologic patients（blood stream infection group） and 120 blood culture-negative hematologic patients（non-blood stream infection group） were enrolled,and the levels of HNL,PCT and TRAIL were determined. The efficiency of each index in diagnosing blood stream infection was evaluated by receiver operating characteristic（ROC） curve. Results The levels of HNL and PCT were higher in bloodstream infection group than those in non-bloodstream infection group（P<0.000 1）,and the level of TRAIL was lower than that in non-bloodstream infection group（P<0.000 1）. Logistic regression analysis was used to list the combined determination models of HNL,PCT and TRAIL,and ROC curve analysis showed that the AUC of HNL,PCT,TRAIL and the combined determination models for blood stream infection were 0.993,0.849,0.938 and 0.996,respectively,and the optimal cut-off values were 60.15 ng/mL,0.85 ng/mL,104.57 pg/mL,0.34,with the sensitivities of 100%,61.7%,90.8% and 100% and the specificities of 97.5%,91.7%,84.2% and 98.4%,respectively. Conclusions HNL,PCT and TRAIL play roles in the diagnosis of bloodstream infection in hematologic patients.

Key words: Human neutrophil lipocalin, Procalcitonin, Tumor necrosis factor-related apoptosis-inducing ligand, Bloodstream infection