Abstract:

Objective To analyze the role of serum procalcitonin （PCT） in the treatment of bloodstream infection in children. Methods Serum PCT of 79 children with bloodstream infection was determined on the 1st,4th and 7th days,respectively,and the clinical data were also collected. Results A total of 37 Gram-positive bacteria and 42 Gram-negative bacteria were isolated. The 1st day PCT of Gram-positive bacteria and 42 Gram-negative bacteria were 7.56（5.33-13.49） ng/mL and 8.96（5.36-21.34） ng/mL,respectively （P>0.05）. On the 4th day,PCT in the 2 groups decreased to 1.10（0.42-3.62） ng/mL and 3.41（1.54-9.95） ng/mL,respectively （P<0.05）. On the 7th day,PCT decreased to 0.13（0.10-0.34） ng/mL and 0.23（0.12-1.92） ng/mL,respectively（P<0.05）. The decreasing rates of PCT differed among different pathogens. Serum PCT of Streptococcus pneumoniae decreased fastly,with 98.57% decreasing on the 4th day and 99.21% decreasing on the 7th day,that of Acinetobacter baumannii decreased slowly,with 33.15% and 46.30% decreasing,respectively. The change of PCT was consistent with the prognosis of children. The antibiotic usage time was 17（11.00-22.50） d. The costs of antibiotics for Gram-positive bacteria and Gram-negative bacteria were 206.34（114.00-389.61） Yuan/d and 297.29（224.62-502.60） Yuan/d,respectively. Conclusions PCT can be used to evaluate the treatment efficiency of antibiotic therapy for bloodstream infection,to adjust the antibiotic usage time and antibiotic therapy timely,which can reduce drug resistance and adverse reactions.

Key words: Bloodstream infection, Procalcitonin, Children, Antibiotic