Abstract:

Objective To investigate the specific changes in the diagnostic efficacy of procalcitonin（PCT） when the diagnostic criteria for sepsis changed from Sepsis-1 to Sepsis-3,and to provide a reference for the clinical application of PCT in the diagnosis of sepsis. Methods A total of 189 patients with infection or（and） the manifestations of systemic inflammatory response syndrome（SIRS）（non-sepsis,sepsis and septic shock groups） and 30 healthy subjects（healthy control group）were enrolled. PCT was determined in all the subjects. Receiver operating characteristic（ROC） curves were used to evaluate the roles of Sepsis-1 and Sepsis-3 for the diagnosis of PCT. Results There was an increasing trend in PCT levels from healthy control,non-sepsis,sepsis to septic shock groups in each diagnostic component（P<0.05）. Based on Sepsis-1 and Sepsis-3 diagnostic criteria,the areas under curves were 0.85 and 0.73,the sensitivities were 76.85% and 57.01%,the specificities were 78.38% and 76.79%,respectively. The areas under curves,sensitivities and specificities of PCT in the diagnosis of septic shock were 0.75 and 0.76,73.91% and 64.86%,80.65% and 81.43%,respectively. Conclusions When the diagnostic criteria for sepsis change from Sepsis-1 to Sepsis-3,the diagnostic efficacy of PCT decreases in the diagnosis of sepsis,and the diagnostic efficacy of PCT does not change in the diagnosis of septic shock.

Key words: Procalcitonin, Sepsis, Sepsis-1, Sepsis-3