Abstract:

Objective　To observe the changes of blood coagulation and fibrinolytic indices after radiofrequency catheter ablation(RFCA) and the restoring time after RFCA. Methods　The levels of D-dimer (DD), von willebrand factor (vWF), tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) were determined in 56 patients undergoing RFCA after intracardiac electrophysiological study before RFCA, just at the time after RFCA and in 2 d and 7 d after RFCA. Results　The levels of DD, vWF and PAI-1 increased significantly after intracardiac electrophysiological study before RFCA, just at the time after RFCA and in 2 d after RFCA (P<0.01), and restored in 7 d after RFCA (P>0.05). The t-PA decreased significantly after intracardiac electrophysiological study before RFCA, just at the time after RFCA and in 2 d after RFCA (P<0.01), and restored in 7 d after RFCA (P>0.05). Conclusions　RFCA may increase the levels of blood coagulation and fibrinolytic indices. Monitoring the levels of D-dimer, vWF, t-PA and PAI-1 is valuable in guiding the administration of anticoagulative drugs and the prophylaxis of thromboembolic events.

Key words: D-dimer, Von willebrand factor, Tissue plasminogen activator, Plasminogen activator inhibitor, Radiofrequency catheter ablation