Abstract:

Objective To investigate the drug resistance of Pseudomonas aeruginosa（PAE） and the correlation between antibiotic usage and drug resistance,in order to provide a reference for clinical rational use of antibiotics.Methods A total of 790 isolates of PAE were collected from January 2010 to December 2014. Kirby-Bauer method was performed for determining the drug susceptibility of PAE to 12 commonly-used antibiotics,and the antibiotics use density（AUD） were counted. The correlation between drug resistance and AUD was analyzed by SPSS 16.0. Results In the past 5 years,the drug resistance rate of PAE to piperacillin-tazobactam decreased from 33.1% in 2010 to 16.5% in 2014（P<0.05）,those to meropenem and imipenem decreased from 42.3% and 39.6% in 2010 to 17.2% and 19.0% in 2014（P<0.05）,and those to amikacin and gentamicin decreased from 13.8% and 39.9% in 2010 to 6.8% and 17.1% in 2014（P<0.05）. The determination rate of multi-drug resistance Pseudomonas aeruginosa（MDRP） was on the decline,and that in 2011（7.5%） was the highest. Carbapenem-resistant group was more frequently resistant to the other antibiotics than carbapenem-susceptible group,and the determination rate of MDRP was also higher（P< 0.05）. There was no statistical significance in determination rates of MDRP between intensive care unit（ICU） and public wards. The drug resistance rate of MDRP to piperacillin-tazobactam（39.5%） was lower than those to imipenem（63.2%） and meropenem（68.4%）（P<0.05）. A correlation was observed between AUD and PAE drug resistance rate（r=0.961,P<0.05）. Conclusions The drug resistance rates of PAE to piperacillin-tazobactam,meropenem,imipenem,amikacin and gentamicin show a downside in the past 5 years,piperacillin-tazobactam could be used as a good choice for the treatment of MDRP. There is a correlation between PAE drug resistance and carbapenem consumption. The prevention and control measures for nosocomial infection and the rational use of antibiotics are effective means to reduce MDRP.

Key words: Pseudomonas aeruginosa, Drug resistance, Antibiotics, Multi-drug resistance, Antibiotics use density