Research progress of cyclic diguanylate on the regulation of Pseudomonas aeruginosa biofilm

doi:10.3969/j.issn.1673-8640.2023.02.017

Abstract

Abstract:

The transition of bacteria from planktonic growth to biofilm（BF） life cycle can promote the adhesion of bacteria to non-biological surfaces，evade host immune system，and increase resistance to common antibiotics. The current BF-forming bacteria have an increasing probability of human infection and greatly increase the energy and time required for treatment and recovery. The second messenger cyclic diguanylate（c-di-GMP） plays a role in the regulation of BF. The research on the treatment of antibiotic-resistant and BF-forming bacteria by directly targeting c-di-GMP signaling has shown promise. Therefore，this review summarizes the effect of c-di-GMP on the regulation of Pseudomonas aeruginosa BF.

Key words: Cyclic diguanylate, Pseudomonas aeruginosa, Biofilm, Regulation

CLC Number:

R446.1

FEI Bing, LIU Ying, REN Yanying, GUO Mengyu, LIU Xinwei, LIU Dongmei, LI Yongwei. Research progress of cyclic diguanylate on the regulation of Pseudomonas aeruginosa biofilm[J]. Laboratory Medicine, 2023, 38(2): 186-189.

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