Research progress on Chinese and western medicine treatment for Candida glabrata infection

doi:10.3969/j.issn.1673-8640.2021.07.018

Abstract

Abstract:

Candida glabrata is the most common non-Candida albicans,and its resistance rate to azoles is increasing year by year,which brings certain difficulty for the clinical treatment of candidiasis. Studies on genes related to resistance of Candida glabrata find that biofilm-related genes and efflux genes are closely related to drug resistance. In order to solve the problem of drug resistance,the drug resistance mechanism of Candida glabrata and the combination of traditional Chinese medicine in the modern clinical treatment of Candida glabrata infection provides a approach of therapy for the clinical treatment of Candida glabrata infection.

Key words: Candida glabrata, Biofilm, Chinese and western medicine treatment, Drug efflux, Drug resistance gene

CLC Number:

R379.4

ZHANG Guanyi, YAO Dongting, WANG Jian, HU Xiaobo. Research progress on Chinese and western medicine treatment for Candida glabrata infection[J]. Laboratory Medicine, 2021, 36(7): 761-765.

References 39

[1]	MADHAVAN P, JAMAL F, PEI C P, et al. Comparative study of the effects of fluconazole and voriconazole on Candida glabrata,Candida parapsilosis and Candida rugosa biofilms[J]. Mycopathologia, 2018, 183(3):499-511. DOI URL
[2]	XIAO M, FAN X, CHEN S C, et al. Antifungal susceptibilities of Candida glabrata species complex,Candida krusei,Candida parapsilosis species complex and Candida tropicalis causing invasive candidiasis in China:3 year national surveillance[J]. J Antimicrob Chemother, 2015, 70(3):802-810. DOI URL
[3]	ALVES I A, BANDEIRA L A, MARIO D A, et al. Effects of antifungal agents alone and in combination against Candida glabrata strains susceptible or resistant to fluconazole[J]. Mycopathologia, 2012, 174(3):215-221. DOI URL
[4]	向小洪, 廖国建. 真菌耐药性研究现状及新型抗真菌药物研究进展[J]. 国外医药(抗生素分册), 2018, 39(5):363-368.
[5]	ANDRADE-PAVÓN D, ORTIE-ÁLVAREZ J, SÁNCHEZ-SANDOVAL E, et al. Inhibition of recombinant enzyme 3-hydroxy-3-methylglutaryl-CoA reductase fromCandida glabrata by α-asarone-based synthetic compounds as antifungal agents[J]. J Biotechnol, 2019, 292:64-67. DOI URL
[6]	侯欣, 徐英春, 赵玉沛. 棘白菌素在念珠菌中的耐药性[J]. 中国真菌学杂志, 2018, 13(1):40-45.
[7]	KUMARI S, KUMAR M, KHANDELWAL N K, et al. ABC transportome inventory of human pathogenic yeast Candida glabrata:phylogenetic and expression analysis[J]. PLoS One, 2018, 13(8):e0202993. DOI URL
[8]	黄金梅, 叶宝国, 沈建箴, 等. 光滑念珠菌两性霉素B耐药株的体外诱导及其耐药分子机制[J]. 中国医院药学杂志, 2014, 34(9):688-692.
[9]	张朋, 王秋霞. FLC与FK506联用对光滑念珠菌耐药性及CDR1、ABC转运蛋白表达的影响[J]. 现代医学, 2017, 45(9):1283-1286.
[10]	刘锦燕, 王影, 李文静, 等. 体外氟康唑诱导光滑念珠菌和近平滑念珠菌耐药及相关机制研究[J]. 诊断学理论与实践, 2017, 16(5):510-515.
[11]	SHAHROKHI S, NOORBAKHSH F, REZAIE S. Quantification of CDR1 gene expression in fluconazole resistant Candida glabrata strains using real-time PCR[J]. Iran J Public Health, 2017, 46(8):1118-1122.
[12]	PAUL S, BAIR T B, MOYE-ROWLEY W S. Identification of genomic binding sites for Candida glabrata Pdr1 transcription factor in wild-type and e0 cells[J]. Antimicrob Agents Chemother, 2014, 58(11):6904-6912. DOI URL
[13]	GOHAR A A, BADALI H, SHOKOHI T, et al. Expression patterns of ABC transporter genes in fluconazole-resistant Candida glabrata[J]. Mycopathologia, 2017, 182(3-4):273-284. DOI URL
[14]	CULAKOVA H, DZUGASOVA V, VALENCIKOVA R, et al. Stress response and expression of fluconazole resistance associated genes in the pathogenic yeast Candida glabrata deleted in the CgPDR16 gene[J]. Microbiol Res, 2015, 174:17-23. DOI URL
[15]	LLOPIS-TORREGROSA V, VAZ C, MONTEOLIVA L, et al. Trk1-mediated potassium uptake contributes to cell-surface properties and virulence of Candida glabrata[J]. Sci Rep, 2019, 9(1):7529. DOI URL
[16]	RODRIGUES C, HENRIQUES M. Portrait of matrix gene expression in Candida glabrata biofilms with stress induced by different drugs[J]. Genes(Basel), 2018, 9(4):205.
[17]	WHALEY S G, CAUDLE K E, VERMITSKY J P, et al. UPC2A is required for high-level azole antifungal resistance in Candida glabrata[J]. Antimicrob Agents Chemother, 2014, 58(8):4543-4554. DOI URL
[18]	VU B G, THOMAS G H, MOYE-ROWLEY W S. Evidence that ergosterol biosynjournal modulates activity of the Pdr1 transcription factor in Candida glabrata[J]. mBio, 2019, 10(3):e00934-19.
[19]	江岑, 董丹凤, 俞焙秦, 等. 3种念珠菌对氟康唑耐药的易感性及耐药机制比较[J]. 中国感染与化疗杂志, 2013, 13(4):296-301.
[20]	LI Q Q, TSAI H F, MANDAL A, et al. Sterol uptake and sterol biosynjournal act coordinately to mediate antifungal resistance in Candida glabrata under azole and hypoxic stress[J]. Mol Med Rep, 2018, 17(5):6585-6597.
[21]	BENEDETTI V P, SAVI D C, ALUIZIO R, et al. ERG11 gene polymorphisms and susceptibility to fluconazole in Candida isolates from diabetic and kidney transplant patients[J]. Rev Soc Bras Med Trop, 2019, 52:e20180473. DOI URL
[22]	DOMINGUEZ E G, ZARNOWSKI R, CHOY H L, et al. Conserved role for biofilm matrix polysaccharides in Candida auris drug resistance[J]. mSphere, 2019, 4(1):e00680-18.
[23]	SPETTEL K, BAROUSCH W, MAKRISTATHIS A, et al. Analysis of antifungal resistance genes in Candida albicans and Candida glabrata using next generation sequencing[J]. PLoS One, 2019, 14(1):e0210397. DOI URL
[24]	BOURGEOIS N, LAURENS C, BERTOUT S, et al. Assessment of caspofungin susceptibility of Candida glabrata by the Etest^®,CLSI,and EUCAST methods,and detection of FKS1 and FKS2 mutations[J]. Eur J Clin Microbiol Infect Dis, 2014, 33(7):1247-1252. DOI URL
[25]	CHEN S M, SHEN H, ZHANG T, et al. Dectin-1 plays an important role in host defense against systemic Candida glabrata infection[J]. Virulence, 2017, 8(8):1643-1656. DOI URL
[26]	张溪, 李芳, 李菁雅. ICU患者深部真菌感染易感因素及中医治疗对预后影响[C]// 首届全国中西医结合重症医学学术会议暨中国中西医结合学会重症医学专业委员会成立大会论文汇编. 北京:中国中西医结合学会, 2010:120-122.
[27]	华国栋, 郑飞, 顾媛媛, 等. 临床药师参与1例中西医结合治疗肺部感染患者的用药分析[J]. 中国药房, 2014, 25(22):2108-2110.
[28]	龚倩玉, 许言超, 左明星, 等. 杜仲内生青霉菌GZWMJZ-068次生代谢产物研究[J]. 天然产物研究与开发, 2018, 30(10):1721-1727.
[29]	张梦翔, 施高翔, 严园园, 等. 姜黄素对5种非白念珠菌菌丝及生物膜形成的抑制作用[J]. 中草药, 2015, 46(4):549-553.
[30]	汪天明, 张梦翔, 施高翔, 等. 黄连解毒汤乙酸乙酯提取物对光滑念珠菌黏附作用的影响[J]. 中国中药杂志, 2015, 40(3):516-521.
[31]	谭妙群, 彭永华. 中西医结合治疗复发性念珠菌性阴道病的临床研究[J]. 中国当代医药, 2018, 25(32):35-37.
[32]	王福君. 中西医结合治疗复发性外阴阴道念珠菌病疗效观察[J]. 内蒙古中医药, 2016, 35(8):66-67.
[33]	刘宁. 复方苦参洗剂联合克霉唑阴道片治疗妊娠期念珠菌性阴道炎临床效果观察[J]. 医学信息, 2018, 31(5):145-146.
[34]	林喜娟. 中西医结合治疗念珠菌性阴道炎的效果研究[J]. 内蒙古中医药, 2017, 36(2):67.
[35]	杨坤, 李红. 中西医结合治疗老年口腔念珠菌病的临床疗效观察[J]. 中国农村卫生, 2017, 10(6):25.
[36]	王维欣, 孙淑娟. 中药成分对氟康唑抗非白色念珠菌的增效作用[J]. 生命的化学, 2014, 34(6):812-816.
[37]	王维欣. 黄连素等纯中药成分对氟康唑抗非白色念珠菌的增敏作用与机制研究[D]. 济南:山东大学, 2015.
[38]	王维欣, 齐丽丽, 赵静, 等. 没食子酸联合氟康唑抗耐药非白念珠菌作用的体外试验[J]. 中国医院药学杂志, 2017, 37(23):2330-2334.
[39]	吴盘红. 香莲方对咪康唑抗念珠菌增效作用的临床和实验研究[D]. 广州:广州中医药大学, 2013.