Abstract:

Objective　To investigate the pathogenetic role and clinical significance of fibrinogen in preeclampsia. Methods　The medical records of 85 healthy pregnant women, 47 mild preeclampsia pregnant patients, 27 severe preeclampsia pregnant patients and 55 healthy women without pregnancy reviewed retrospectively. The predictive value of fibrinogen levels was assessed by receiver operating characteristic (ROC) curve. Pearson method was used to analyze the correlation between fibrinogen and the time of preeclampsia onset. Results　Preeclampsia pregnant patients had higher plasma fibrinogen, compared with either healthy pregnant women or healthy women without pregnancy (P<0.01). The areas under ROC curve of fibrinogen for mild and severe preeclampsia [95% confidence interval (CI)]were 0.70 (0.62-0.78) and 0.70 (0.58-0.82). Negative correlation was observed between plasma fibrinogen and the time of preeclampsia onset (R＝－0.33，P<0.01). Conclusions　Plasma fibrinogen is helpful for preeclampsia prediction.

Key words: Preeclampsia, Fibrinogen, Pregnancy