The changes of serum alpha2-Heremans-Schmid glycoprotein level and its correlation with CRP in patients with diabetic retinopathy

doi:10.3969/j.issn.1673-8640.2014.10.012

Abstract

Abstract: Objective To investigate the changes of serum alpha2-Heremans-Schmid glycoprotein(AHSG)level and its correlation with C-reactive protein (CRP) in patients with diabetic retinopathy (DR). Methods Serum levels of AHSG and CRP were determined by enzyme-linked immunosorbent assay (ELISA) in 115 type 2 diabetes mellitus(T2DM) patients, and the 115 T2DM patients were classified into 3 groups, 46 patients with non-diabetic retinopathy(NDR), 37 patients with non-proliferative diabetic retinopathy (NPDR) and 32 patients with proliferative diabetic retinopathy (PDR). A total of 40 healthy controls were enrolled. Resutls The serum levels of AHSG and CRP in NDR group, NPDR group and PDR group were higher than that in healthy control group, and there was statistical significance among the groups(P<0.05, P<0.01). Serum AHSG level in T2DM patients was positively correlated with CRP (r=0.239, P<0.05). Conclusions The increasing of AHSG level is correlated with the severity of DR, and it may be involved in the development and pathogenesis of DR by proinflammatory effects.

Key words: Diabetic retinopathy, Alpha2-Heremans-Schmid glycoprotein, C-reactive protein

CLC Number:

R446.1

ZHOU Zhongwei, SUN Mingzhong, JU Huixiang, JI Yuqiao, GU Juan, JI Fei, DING Fuwan, JIANG Dongmei. The changes of serum alpha2-Heremans-Schmid glycoprotein level and its correlation with CRP in patients with diabetic retinopathy[J]. , 2014, 29(10): 1034-1036.

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