Abstract:

Objective To study the drug resistance of Klebsiella pneumoniae to common antibiotics, and to measure the mutant prevention concentration (MPC) of fluoroquinolone (FQNs) and analyze the anti-drug resistance mutation ability. Methods The minimum inhibition concentration (MIC) was determined by micro-dilution method, and MPC was determined by agar dilution method. The drug resistance to common antibiotics was measured by K-B method. Results A total of 30 clinical isolates of Klebsiella pneumoniae had extended-spectrum beta lactamases (ESBLs) positive (15 isolates, positive group) and negative (15 isolates, negative group). The results showed that the drug resistance to common antibiotics had significant difference. The drug resistance rate of ESBLs positive group was higher than that of ESBLs negative group.The MPC, MIC anddrug resistance selection index (SI) of levofloxacin and moxifloxacin for ESBLs positive and ESBLs negative Klebsiella pneumoniae showed different distribution characteristics. Conclusions For the 30 isolates of Klebsiella pneumoniae, the drug resistance to common antibiotics of ESBLs positive isolates is serious, and MPC and SI are significantly higher than those of ESBLs negative isolates.

Key words: Klebsiella pneumoniae, Drug resistance, Mutant prevention concentration, Extended-spectrum beta lactamase