Research progress on the drug resistance mechanism of clinical pathogens to fosfomycin

doi:10.3969/j.issn.1673-8640.2022.010.017

Abstract

Abstract:

With the spread of multidrug-resistant or extensively drug resistant pathogens and the lack of new antibiotics，many old antibiotics，such as fosfomycin and polymyxin，are reused for anti-infection treatment in clinic. Fosfomycin has a unique mechanism against Gram-positive and Gram-negative bacteria. Cross-resistance is not common. This review mainly focuses on drug resistance mechanism to fosfomycin，such as drug resistance caused by murA mutations，mutations in the chromosomal genes encoding fosfomycin transporters，acquisition of plasmid-encoded genes encoding fosfomycin-modifying enzymes and hetero-resistance to fosfomycin.

Key words: Fosfomycin, Drug resistance mechanism, murA mutation, Membrane transporter, Fosfomycin-modifying enzyme, Hetero-resistance

CLC Number:

R446.5

WANG Lixin, SU Yunfu, WANG Yi. Research progress on the drug resistance mechanism of clinical pathogens to fosfomycin[J]. Laboratory Medicine, 2022, 37(10): 993-997.

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