关键词: 肿瘤标志物, 中医证型, 肺癌

Abstract: Objective　To investigate the coorelation of pathological diagnosis，TNM stage and the levels of tumor markers with different scenarios of traditional Chinese medicine syndrome in patients with lung cancer. Methods　A total of 196 patients had been diagnosed with lung cancer. The correlation analysis of pathological diagnosis[non-small cell lung cancer(squamous carcinoma， adenocarcinoma， large cell carcinoma and mixed cell carcinoma) and small cell lung cancer]，TNM stage and tumor markers[cytokerantin-19-fragment(CYFRA21-1)，carcinoembryonic antigen (CEA)，carbohydrate antigen 125(CA125)，pro-gastrin-releasing peptide(ProGRP) and squamous cell carcinoma antigen(SCC Ag)] with different scenarios of traditional Chinese medicine syndrome in patients with lung cancer was performed.  Results　Most of the traditional Chinese medicine syndromes in lung cancer patients were lung and spleen deficiency syndrome(119 cases， 60.71%)， Qi and Yin deficiency syndrome(76 cases， 38.7%) and spleen and kidney deficiency syndrome(1 case， 0.52%). However，the distribution of the traditional Chinese medicine syndrome among the different pathological diagnosis in lung cancer patients showed no significant difference （P=0.325）. Lung and spleen deficiency syndrome was concentrated in TNM stage Ⅰ-Ⅲ patients，while Qi and Yin deficiency syndrome was concentrated in TNM stage Ⅳ patients. The CYFRA21-1 levels in Qi and Yin deficiency syndrome patients were higher than those in lung and spleen deficiency syndrome patients（P=0.017）. The differences of CEA，CA125，ProGRP and SCC Ag levels were not significant （P＞0.05）. Conclusions　Most of the lung cancer patients are deficiency syndrome. It indicates that advanced stage lung cancer patients would be in unstable conditions and have bad prognosis when Qi and Yin deficiency. CYFRA21-1 and other tumor markers could be the microscopic evidence to traditional Chinese medicine syndrome diagnosis.

Key words: Tumor marker, Traditional Chinese medicine syndrome, Lung cancer