胰岛素样生长因子1及其结合蛋白3对胃癌诊断的意义

doi:10.3969/j.issn.1673-8640.2013.05.011

检验医学 ›› 2013, Vol. 28 ›› Issue (5): 391-395.DOI: 10.3969/j.issn.1673-8640.2013.05.011

胰岛素样生长因子1及其结合蛋白3对胃癌诊断的意义

彭冲,孙桂荣

青岛大学医学院附属医院检验科，山东青岛 266003

收稿日期:2012-10-18 修回日期:2013-01-07 出版日期:2013-05-15 发布日期:2013-05-14
通讯作者: 孙桂荣，联系电话：0532-82911773。
作者简介:彭冲，男，1987年生，硕士，主要从事临床免疫学研究。

The significance of IGF-1 and IGFBP-3 in the diagnosis of gastric cancer

Department of Clinical Laboratory，the Affiliated Hospital of Qingdao University Medical College，Shandong Qingdao 266003，China

Received:2012-10-18 Revised:2013-01-07 Online:2013-05-15 Published:2013-05-14

摘要/Abstract

摘要： 目的　评估血清胰岛素样生长因子-1(IGF-1)及胰岛素样生长因子结合蛋白-3(IGFBP-3)对胃癌及胃癌前病变的临床诊断价值。方法　采用化学发光法、酶联免疫吸附试验（ELISA）和电化学发光法对90例胃癌患者、40例胃良性疾病患者和50名健康体检者血清IGF-1、IGFBP-3、癌胚抗原（CEA）和糖类抗原199（CA199）水平进行检测。结果　胃癌组血清IGF-1水平明显高于胃良性疾病组和健康对照组(P＜0.05、P＜0.001），血清IGFBP-3水平明显低于胃良性疾病组和健康对照组(P＜0.001)；胃癌早期(Ⅰ~Ⅱ期)组血清IGF-1水平虽明显低于胃癌晚期(Ⅲ~Ⅳ期)组，但高于健康对照组；IGFBP-3水平虽高于胃癌晚期组，但也低于健康对照组。血清IGF-1与IGFBP-3呈明显负相关，直线相关方程为Y =-0.33X+116.65(r=-0.566，P＜0.01)；血清IGF-1、IGFBP-3与CEA、CA199均无相关性。以健康对照组为对照绘制受试者工作特征(ROC)曲线，IGF-1的ROC曲线下面积（AUC）明显高于CEA和CA199(P＜0.01、P＜0.05)，诊断胃癌的敏感性亦高于CEA和CA199(P＜0.05)。结论　IGF-1对胃癌的诊断价值优于CEA和CA199，且有助于胃癌分期的评估。

关键词: 胰岛素样生长因子-1, 胰岛素样生长因子结合蛋白-3, 胃癌, 胃癌前病变

Abstract: Objective　To evaluate the clinical significance of serum insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGFBP-3) in the diagnosis of gastric cancer and gastric precancerous lesion. Methods　The serum levels of IGF-1，IGFBP-3，carcinoembryonic antigen (CEA) and carbohydrate antigen 199(CA199) were measured by chemiluminescence immunoassay，enzyme-linked immunosorbent assay(ELISA) and electro-chemiluminescence immunoassay in 90 patients with gastric cancer，40 patients with gastric benign disease and 50 healthy subjects. Results　The serum levels of IGF-1 in patients with gastric cancer were significantly higher than those in patients with gastric benign disease and healthy subjects（P＜0.05，P＜0.001）. The serum levels of IGFBP-3 in patients with gastric cancer were significantly lower than those in patients with gastric benign disease and healthy subjects(P＜0.001).The serum levels of IGF-1 in the early (Ⅰ-Ⅱ) stage of gastric cancer were lower than those in the late (Ⅲ-Ⅳ) stage， but were higher than those in the healthy subjects，and the serum levels of IGFBP-3 were higher than those in the late stage， but were lower than those in the healthy subjects.The serum levels of IGF-1 had significantly negative correlation with IGFBP-3，and the linear correlation equation was Y =-0.33X +116.65(r=-0.566，P＜0.01). There was no correlation between IGF-1 and IGFBP-3 with CEA and CA199. Using the healthy subjects as controls，the areas under the receiver operating characteristic(ROC) curve (AUC) of IGF-1 was obviously higher than those of CEA and CA199(P＜0.01，P＜0.05). The sensitivity of IGF-1 for the diagnosis of gastric cancer was higher than those of CEA and CA199(P＜0.05). Conclusions　IGF-1 is better than CEA and CA199， in the diagnosis of gastric cancer，and it is helpful for the evaluation of gastric cancer stages.

Key words: Insulin-like growth factor-1, Insulin-like growth factor binding protein-3, Gastric cancer, Gastric precancerous lesion

彭冲，孙桂荣，张娜娜，高振亮，吕晓玉荣. 胰岛素样生长因子1及其结合蛋白3对胃癌诊断的意义[J]. 检验医学, 2013, 28(5): 391-395.

PENG Chong，SUN Guirong，ZHANG Nana，GAO Zhenliang，Lü Xiaoyu. The significance of IGF-1 and IGFBP-3 in the diagnosis of gastric cancer[J]. , 2013, 28(5): 391-395.

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胰岛素样生长因子1及其结合蛋白3对胃癌诊断的意义

The significance of IGF-1 and IGFBP-3 in the diagnosis of gastric cancer

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