EB病毒相关胃癌迁移、侵袭相关miRNA和lncRNA研究进展

doi:10.3969/j.issn.1673-8640.2023.10.016

摘要/Abstract

摘要：

胃癌是全球第五大常见恶性肿瘤，死亡率居肿瘤相关死亡的第3位。EB病毒（EBV）感染在人群中非常普遍，与各种人类肿瘤有关，如鼻咽癌、胃癌和淋巴瘤，其中EB病毒相关胃癌（EBVaGC）约占所有胃癌的1.3%~30.9%。在EBV相关肿瘤中，许多非编码RNA（ncRNA）参与了肿瘤细胞增殖、迁移和侵袭等过程的调控，ncRNA与潜在靶基因的相互作用逐渐成为研究热点。文章综述了与胃癌迁移、侵袭相关的ncRNA的研究进展，以期为后续胃癌的研究提供参考。

关键词: 非编码RNA, 迁移, 侵袭, EB病毒, 胃癌

Abstract:

Gastric cancer is the fifth most common malignancy worldwide and has the third highest mortality rate among cancer-related deaths. Epstein-Barr virus（EBV） infection is highly prevalent in the population and is known to be associated with various human cancers，such as nasopharyngeal cancer，gastric cancer and lymphoma. The Epstein-Barr virus-associated gastric cancer（EBVaGC） accounts for 1.3%-30.9% of all gastric cancers. Many non-coding RNA（ncRNA） have been shown to be involved in the regulation of proliferation，migration and invasion processes in EBV-associated cancers，and the interaction between ncRNA and potential target genes is gradually becoming a research hot-spot. Therefore，this review focuses on the research progress of ncRNA related to migration and invasion in gastric cancer，with a view to providing a reference for subsequent research on gastric cancer.

Key words: Non-coding RNA, Migration, Invasion, Epstein-Barr virus, Gastric cancer

中图分类号:

R446.1

郭霜, 刘红莉, 李娅. EB病毒相关胃癌迁移、侵袭相关miRNA和lncRNA研究进展[J]. 检验医学, 2023, 38(10): 987-996.

GUO Shuang, LIU Hongli, LI Ya. Progression of migration and invasion-related miRNA and lncRNA in Epstein-Barr virus-associated gastric cancer[J]. Laboratory Medicine, 2023, 38(10): 987-996.

图/表 3

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EBV ncRNA	结合靶点	宿主ncRNA	迁移侵袭	凋亡	EMT	信号通路/信号轴
miR-BART1-3p^[14,29]	PTEN，DAB2		促进	抑制		PI3K/Akt，Akt/FAK/p130和Shc/MAPK通路
miR-BART1-5p^[14]	PTEN		促进		促进	PI3K-Akt，Akt/FAK/p130和Shc/MAPK通路
miR-BART2-5p^[17]	RB，p21		促进
miR-BART3-3p^[19]	p21		促进
miR-BART3-5p^[19]	DICE1		促进
miR-BART4-5p^[14]	PTEN，Bid		促进	抑制
miR-BART5-3p^[31]	p53			抑制
miR-BART5-5p^[32]	PUMA，PIAS3		促进	抑制		miR-BART5/PIAS3/pSTAT3/PD-L1
miR-BART6-3p^[35]		Lnc-LOC553103	抑制	促进		LOC553103-STMN1信号轴
miR-BART7^[26]	Snail，β-catenin				促进
miR-BART8-3p^[11]	RNF38		促进			NF-κB和ERK1/2信号通路
miR-BART9-3p^[24]	CDH1	hsa-miR-200a hsa-miR-141			促进	miR-200/ZEB1/E-Cad信号轴
miR-BART9-5p^[24]	CDH1	hsa-miR-200a hsa-miR-141			促进	miR-200/ZEB1/E-Cad信号轴
miR-BART10-3p^[13]	APC，DKK1，BTRC		促进		促进	激活Wnt信号通路
miR-BART11^[27]	Foxp1，RB，p21		促进		促进
miR-BART15^[28]	TAX1BP1，NLRP3，TAX1BP1		抑制	促进
miR-BART17-5p^[15-16]	KLF2，LMP2A		促进
miR-BART20-5p^[34]	BAD		促进	抑制
miR-BART22^[13]	APC，DKK1，LMP2A		促进			激活Wnt信号通路
circRNA-LMP2A^[67]	hsa-miR-3908		促进			KHSRP/VHL/HIF-1α/VEGFA信号轴
circRNA-RPMS1^[68]	METTL3		促进

EBV ncRNA	结合靶点	宿主ncRNA	迁移侵袭	凋亡	EMT	信号通路/信号轴
miR-BART1-3p^[14,29]	PTEN，DAB2		促进	抑制		PI3K/Akt，Akt/FAK/p130和Shc/MAPK通路
miR-BART1-5p^[14]	PTEN		促进		促进	PI3K-Akt，Akt/FAK/p130和Shc/MAPK通路
miR-BART2-5p^[17]	RB，p21		促进
miR-BART3-3p^[19]	p21		促进
miR-BART3-5p^[19]	DICE1		促进
miR-BART4-5p^[14]	PTEN，Bid		促进	抑制
miR-BART5-3p^[31]	p53			抑制
miR-BART5-5p^[32]	PUMA，PIAS3		促进	抑制		miR-BART5/PIAS3/pSTAT3/PD-L1
miR-BART6-3p^[35]		Lnc-LOC553103	抑制	促进		LOC553103-STMN1信号轴
miR-BART7^[26]	Snail，β-catenin				促进
miR-BART8-3p^[11]	RNF38		促进			NF-κB和ERK1/2信号通路
miR-BART9-3p^[24]	CDH1	hsa-miR-200a hsa-miR-141			促进	miR-200/ZEB1/E-Cad信号轴
miR-BART9-5p^[24]	CDH1	hsa-miR-200a hsa-miR-141			促进	miR-200/ZEB1/E-Cad信号轴
miR-BART10-3p^[13]	APC，DKK1，BTRC		促进		促进	激活Wnt信号通路
miR-BART11^[27]	Foxp1，RB，p21		促进		促进
miR-BART15^[28]	TAX1BP1，NLRP3，TAX1BP1		抑制	促进
miR-BART17-5p^[15-16]	KLF2，LMP2A		促进
miR-BART20-5p^[34]	BAD		促进	抑制
miR-BART22^[13]	APC，DKK1，LMP2A		促进			激活Wnt信号通路
circRNA-LMP2A^[67]	hsa-miR-3908		促进			KHSRP/VHL/HIF-1α/VEGFA信号轴
circRNA-RPMS1^[68]	METTL3		促进