糖尿病足患者FGF-2、Lp-PLA2及IGF-1水平与病情的相关性分析

doi:10.3969/j.issn.1673-8640.2022.09.005

摘要/Abstract

摘要：

目的探讨糖尿病足患者血清成纤维细胞生长因子2（FGF-2）、脂蛋白相关磷脂酶A2（Lp-PLA2）及胰岛素样生长因子-1（IGF-1）水平变化,及其与病情严重程度的相关性。方法选取糖尿病足患者120例（糖尿病足组）,按Wagner分级标准将所有患者分为0~1级组（40例）、2~3级组（48例）、4~5级组（32例）。另选取单纯2型糖尿病（T2DM）患者60例（T2DM组）,以体检健康者60名作为正常对照组。检测所有对象血清FGF-2、Lp-PLA2及IGF-1水平。采用Spearman相关分析评价FGF-2、Lp-PLA2及IGF-1与Wagner分级的相关性。结果正常对照组、T2DM组及糖尿病足组血清FGF-2、Lp-PLA2水平依次升高（P<0.05）,血清IGF-1水平依次降低（P<0.05）。糖尿病足患者中,0~1级组、2~3级组、4~5级组血清FGF-2、Lp-PLA2水平依次升高（P<0.05）,血清IGF-1水平依次降低（P<0.05）。血清FGF-2、Lp-PLA2水平与Wagner分级呈正相关（r值分别为0.652、0.665,P<0.05）,血清IGF-1水平与Wagner分级呈负相关（r=-0.643,P<0.05）。结论血清FGF-2、Lp-PLA2及IGF-1水平与糖尿病足病情严重程度密切相关。

关键词: 成纤维细胞生长因子2, 脂蛋白相关磷脂酶 A2, 胰岛素样生长因子-1, 糖尿病足

Abstract:

Objective To investigate the changes of serum fibroblast growth factor 2（FGF-2）,lipoprotein-related phospholipase A2（Lp-PLA2） and insulin-like growth factor-1（IGF-1） levels in patients with diabetic foot and the correlation with disease severity. Methods A total of 120 diabetic foot patients were enrolled as diabetic foot group. According to the Wagner classification,the diabetic foot patients were classified into grade 0-1 group（40 cases） and grade 2-3 group（48 cases） and grade 4-5 group（32 cases）. Totally,60 type 2 diabetes mellitus（T2DM）patients were enrolled as T2DM group,and 60 healthy subjects were enrolled as control group. The changes of serum FGF-2,Lp-PLA2 and IGF-1 levels were evaluated,and Spearman method was used to analyze the correlation between the above indicators and the degree of diabetic foot disease. Results The levels of serum FGF-2 and Lp-PLA2 in control group,T2DM group and diabetic foot group were increased in turn（P<0.05）,and the level of serum IGF-1 was decreased in turn（P<0.05）. In diabetic foot patients,the levels of serum FGF-2 and Lp-PLA2 in grade 0-1 group,grade 2-3 group and grade 4-5 group were increased in turn（P<0.05）,while serum IGF-1 level was decreased in turn（P<0.05）. Serum FGF-2 and Lp-PLA2 levels were positively correlated with Wagner grade（r values were 0.652 and 0.665,P<0.05）,and serum IGF-1 level was negatively correlated with Wagner grade（r=-0.643,P<0.05）. Conclusions Serum FGF-2,Lp-PLA2 and IGF-1 levels are closely related to the disease severity of diabetic foot.

Key words: Fibroblast growth factor 2, Lipoprotein-related phospholipase A2, Insulin-like growth factor-1, Diabetic foot

中图分类号:

R446.1

张城, 费春霞, 付琳, 高辰飞, 倪冬英. 糖尿病足患者FGF-2、Lp-PLA2及IGF-1水平与病情的相关性分析[J]. 检验医学, 2022, 37(9): 826-830.

ZHANG Cheng, FEI Chunxia, FU Lin, GAO Chenfei, NI Dongying. Correlation analysis of FGF-2,Lp-PLA2 and IGF-1 levels and disease severity in patients with diabetic foot[J]. Laboratory Medicine, 2022, 37(9): 826-830.

图/表 6

参考文献 17

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组别	例数	糖尿病病程/年	HbA_lc/%	TC/（mmol/L）	HDL-C/（mmol/L）	LDL-C/（mmol/L）
正常对照组	60		5.13±0.72	4.69±0.56	1.50±0.24	2.95±0.53
T2DM组	60	7.84±2.46	9.23±2.73^*	4.58±0.52	1.17±0.25^*	3.18±0.46^*
糖尿病足组	120	10.56±2.83^#	9.84±2.81^*	4.71±0.59	1.01±0.22^*#	3.24±0.37^*
统计值		5.619	78.062	1.094	88.602	8.945
P值		0.000	0.000	0.337	0.000	0.000

组别	例数	糖尿病病程/年	HbA_lc/%	TC/（mmol/L）	HDL-C/（mmol/L）	LDL-C/（mmol/L）
正常对照组	60		5.13±0.72	4.69±0.56	1.50±0.24	2.95±0.53
T2DM组	60	7.84±2.46	9.23±2.73^*	4.58±0.52	1.17±0.25^*	3.18±0.46^*
糖尿病足组	120	10.56±2.83^#	9.84±2.81^*	4.71±0.59	1.01±0.22^*#	3.24±0.37^*
统计值		5.619	78.062	1.094	88.602	8.945
P值		0.000	0.000	0.337	0.000	0.000

组别	例数	FGF-2/（ng/mL）	Lp-PLA2/（ng/mL）	IGF-1/（ng/mL）
正常对照组	60	4.64±1.11	124.69±31.13	143.92±38.28
T2DM组	60	10.53±2.84^*	240.69±57.15^*	86.22±22.27^*
糖尿病足组	120	17.17±5.22^*#	316.77±79.46^*#	58.52±16.71^*#
F值		204.835	175.441	232.176
P值		0.000	0.000	0.000

组别	例数	FGF-2/（ng/mL）	Lp-PLA2/（ng/mL）	IGF-1/（ng/mL）
正常对照组	60	4.64±1.11	124.69±31.13	143.92±38.28
T2DM组	60	10.53±2.84^*	240.69±57.15^*	86.22±22.27^*
糖尿病足组	120	17.17±5.22^*#	316.77±79.46^*#	58.52±16.71^*#
F值		204.835	175.441	232.176
P值		0.000	0.000	0.000

组别	例数	FGF-2/（ng/mL）	Lp-PLA2/（ng/mL）	IGF-1/（ng/mL）
0~1级组	40	13.51±3.59	255.73±48.95	72.22±14.68
2~3级组	48	16.58±4.19^*	316.94±62.94^*	56.33±13.02^*
4~5级组	32	22.64±3.65^*#	392.81±66.64^*#	44.68±9.80^*#
F值		50.714	46.832	41.913
P值		0.000	0.000	0.000