体液piRNA作为疾病潜在生物标志物的研究进展

doi:10.3969/j.issn.1673-8640.2022.08.015

摘要/Abstract

摘要：

PIWI蛋白相互作用RNA（piRNA）是一类可以沉默转座子及调控mRNA翻译的新型非编码小RNA。piRNA主要参与生殖细胞的发育和精子的发生,与肿瘤等疾病的发生、发展也密切相关。在特定疾病状态下,体液中的piRNA会出现差异表达,具有作为新型生物标志物的潜力。文章就体液piRNA作为各种疾病潜在的生物标志物的研究进展作一综述。

关键词: PIWI蛋白相互作用RNA, 体液, 生物标志物

Abstract:

PIWI-interacting RNA（piRNA）is a new class of small non-coding RNA that can silence transposon and regulate mRNA translation. Previous studies have shown that piRNA is mainly involved in germ cell development and spermatogenesis,and it is closely related to tumorigenesis and other diseases. The differential expression levels of piRNA in body fluid under specific disease states suggest that piRNA have the potential to be a new biomarker. The review focuses on the progress of research on body fluid piRNA as a potential biomarker for various diseases.

Key words: PIWI-interacting RNA, Body fluid, Biomarker

中图分类号:

R446.7

邬燕倩, 俞翀, 沈鹭, 郑浩然, 洪叶挺. 体液piRNA作为疾病潜在生物标志物的研究进展[J]. 检验医学, 2022, 37(8): 782-786.

WU Yanqian, YU Chong, SHEN Lu, ZHENG Haoran, HONG Yeting. Research progress of body fluid piRNA as a potential biomarker of disease[J]. Laboratory Medicine, 2022, 37(8): 782-786.

图/表 1

参考文献 38

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样本类型	piRNA	疾病	表达量	临床分析
外周血	piR-651、piR-823	胃癌	降低	TNM分期和远隔转移
外周血	piR-5937、piR-28876	结直肠癌	降低	诊断、TNM分期
外周血	piR-017724	结直肠癌	降低	诊断和预后
外周血	piR-54265	结直肠癌	升高	筛查、早期检测和临床监测
外周血	piR-020619、piR-020450	结直肠癌	升高	早期检测
外周血	piR-823	结直肠癌	升高	诊断TNM分期
外周血	piR-10506469、piR-20548188	胆管癌和胆囊癌	升高	诊断和预后
外周血	piR-651	霍奇金淋巴瘤	降低	评估生存期和预后
外周血	piR-823	多发性骨髓瘤	升高	诊断、分期和预后
外周血	piR-020009、piR-006426	心力衰竭	降低	诊断
外周血	piR-012753、piR-016735	慢性阻塞性肺疾病	升高	区分慢性阻塞性肺疾病患者与吸烟者、非吸烟者
外周血	piR-009228、piR-016659、piR-020496	非综合征型唇腭裂	升高	产前筛查畸形儿
外周血	piR-5936	膀胱癌	升高	膀胱癌风险等级评估
外周血	piR-26399	男性不育	升高	诊断
精浆	piR-1207、piR-2107	弱精症	降低	诊断
精浆	piR-61927	非梗阻性无精症	降低	睾丸显微取精术结果评估
尿液	piR-823	肾细胞肾癌	升高	诊断
尿液	piR-018849、piR-019324	前列腺疾病	降低	鉴别前列腺增生和前列腺癌
骨髓上清液	piR-004800	多发性骨髓瘤	升高	多发性骨髓瘤分期

样本类型	piRNA	疾病	表达量	临床分析
外周血	piR-651、piR-823	胃癌	降低	TNM分期和远隔转移
外周血	piR-5937、piR-28876	结直肠癌	降低	诊断、TNM分期
外周血	piR-017724	结直肠癌	降低	诊断和预后
外周血	piR-54265	结直肠癌	升高	筛查、早期检测和临床监测
外周血	piR-020619、piR-020450	结直肠癌	升高	早期检测
外周血	piR-823	结直肠癌	升高	诊断TNM分期
外周血	piR-10506469、piR-20548188	胆管癌和胆囊癌	升高	诊断和预后
外周血	piR-651	霍奇金淋巴瘤	降低	评估生存期和预后
外周血	piR-823	多发性骨髓瘤	升高	诊断、分期和预后
外周血	piR-020009、piR-006426	心力衰竭	降低	诊断
外周血	piR-012753、piR-016735	慢性阻塞性肺疾病	升高	区分慢性阻塞性肺疾病患者与吸烟者、非吸烟者
外周血	piR-009228、piR-016659、piR-020496	非综合征型唇腭裂	升高	产前筛查畸形儿
外周血	piR-5936	膀胱癌	升高	膀胱癌风险等级评估
外周血	piR-26399	男性不育	升高	诊断
精浆	piR-1207、piR-2107	弱精症	降低	诊断
精浆	piR-61927	非梗阻性无精症	降低	睾丸显微取精术结果评估
尿液	piR-823	肾细胞肾癌	升高	诊断
尿液	piR-018849、piR-019324	前列腺疾病	降低	鉴别前列腺增生和前列腺癌
骨髓上清液	piR-004800	多发性骨髓瘤	升高	多发性骨髓瘤分期