肝素结合蛋白在感染性疾病中的应用研究进展

doi:10.3969/j.issn.1673-8640.2021.11.019

摘要/Abstract

摘要：

目前,临床常用的感染性疾病辅助诊断指标有白细胞（WBC）、中性粒细胞、C反应蛋白（CRP）、降钙素原（PCT）、红细胞沉降率（ESR）、白细胞介素6（IL-6）等,但这些指标均存在准确性较低、敏感性不足及特异性较差的缺点。在感染性疾病的预防和治疗中,如何尽早采取合理的应对措施是治疗成功的关键。近几年来,随着对肝素结合蛋白（HBP）研究的不断深入,其在感染性疾病早期诊断中的作用逐渐被揭示出来。文章对HBP在感染性疾病中的临床价值进行综述。

关键词: 肝素结合蛋白, 感染性疾病, 生物标志物

Abstract:

The clinically commonly used auxiliary diagnostic indicators for infectious diseases include white blood cell（WBC） count,neutrophil,C-reactive protein（CRP）,procalcitonin（PCT）,erythrocyte sedimentation rate（ESR） and interleukin 6（IL-6）. However,these indicators all have the defects of low accuracy,insufficient sensitivity and poor specificity to various degrees. In the prevention and treatment of infectious diseases,how to take reasonable response measures as soon as possible is the key to successful treatment. In the recent years,with the continuous in-depth study of heparin-binding protein（HBP）,its role in the early diagnosis of infectious diseases has gradually been revealed. This review focuses on the clinical value of HBP in infectious diseases.

Key words: Heparin-binding protein, Infectious disease, Clinical diagnosis

中图分类号:

R446.1

张万乾, 王想福, 任有亮, 郑卉卉. 肝素结合蛋白在感染性疾病中的应用研究进展[J]. 检验医学, 2021, 36(11): 1186-1189.

ZHANG Wanqian, WANG Xiangfu, REN Youliang, ZHENG Huihui. Application progress of heparin-binding protein in infectious diseases[J]. Laboratory Medicine, 2021, 36(11): 1186-1189.

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