电化学适配体传感器检测生物标志物研究进展

doi:10.3969/j.issn.1673-8640.2022.05.016

摘要/Abstract

摘要：

适配体可特异性识别疾病的生物标志物,利用适配体这一特性建立的检测方法在临床应用中越来越受到关注。随着适配体生物传感器的开发,其应用前景也随之展现。适配体与功能纳米材料结合可提高检测灵敏度,降低检出限。文章对采用适配体纳米技术构建电化学生物传感器的方法,如何改进生物传感器的性能,以及生物传感器在疾病生物标志物检测方面的应用进行介绍,并分析电化学适配体生物传感器的应用前景和面临的挑战。

关键词: 适配体, 生物标志物, 电化学生物传感器

Abstract:

Aptamers have attracted more and more attention in clinical determination due to their specific recognition of disease biomarkers. At present,there have been many research reports,using aptamers to identify biomarkers to form determination method which has detectable signals. With the development of aptamer biosensors,its application prospects are also revealed. The combination of aptamers and functional nanomaterials can improve determination sensitivity and reduce determination limit. This review introduces the method of aptamer nanotechnology to construct electrochemical biosensors and how to improve the performance of biosensors. The application of biosensors in the determination of disease biomarkers is exemplified. The application prospects and challenges of aptamer biosensors are discussed in this review as well.

Key words: Aptamer, Biomarker, Electrochemical biosensor

冯雪晴, 居漪, 李卿, 金中淦. 电化学适配体传感器检测生物标志物研究进展[J]. 检验医学, 2022, 37(5): 477-482.

FENG Xueqing, JU Yi, LI Qing, JIN Zhonggan. Research progress of electrochemical aptasensors for the determination of biomarkers[J]. Laboratory Medicine, 2022, 37(5): 477-482.

图/表 3

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