检验医学 ›› 2020, Vol. 35 ›› Issue (5): 501-505.DOI: 10.3969/j.issn.1673-8640.2020.05.023
马英博 综述, 曹文俊 审校
收稿日期:
2019-04-28
出版日期:
2020-05-30
发布日期:
2020-06-17
作者简介:
null作者简介:马英博,女,1996年生,学士,主要从事特殊感受器的检验医学研究与临床检验工作。
MA Yingbo, CAO Wenjun
Received:
2019-04-28
Online:
2020-05-30
Published:
2020-06-17
摘要:
外周血中性粒细胞/淋巴细胞比值(NLR)是一项免疫炎症指标,NLR异常升高可提示恶性肿瘤、自身免疫性疾病和心血管疾病等预后不良。最近研究发现,慢性炎症可能参与青光眼、糖尿病视网膜病变(DR)、黄斑变性、干眼症(DED)等眼部疾病的发生和发展,因此许多学者对NLR与多种眼部疾病的关系进行了探究。文章就目前NLR主要临床应用及其在部分眼部疾病中的研究进展进行了综述。
中图分类号:
马英博 综述, 曹文俊 审校. 中性粒细胞/淋巴细胞比值在眼部疾病中的研究进展[J]. 检验医学, 2020, 35(5): 501-505.
MA Yingbo, CAO Wenjun. Research progress on neutrophil to lymphocyte ratio in eye diseases[J]. Laboratory Medicine, 2020, 35(5): 501-505.
研究病种 | 参考文献 | 时间 | 样本量 | 检测指标 |
---|---|---|---|---|
POAG | [22] | 2016 | 258 | NLR、PLR |
PXG | [23] | 2016 | 105 | NLR、PLR |
PACG | [21] | 2017 | 1 541 | NLR、LMR |
AMD | [25] | 2015 | 245 | NLR |
AMD | [44] | 2015 | 129 | NLR |
AMD | [26] | 2016 | 120 | NLR、CRP |
AMD | [28] | 2017 | 326 | NLR |
AMD | [29] | 2017 | 200 | NLR、PLR |
AMD | [45] | 2018 | 178 | NLR、PLR、MLR |
DR | [32] | 2011 | 30 973 | NLR |
DR | [46] | 2013 | 110 | NLR |
DR | [47] | 2013 | 460 | NLR |
DR | [48] | 2015 | 402 | NLR |
DR | [49] | 2015 | 114 | NLR |
DR | [50] | 2015 | 188 | NLR、MLR |
DED | [36] | 2018 | 65 | NLR、CRP |
DED | [35] | 2016 | 138 | NLR |
AAION | [38] | 2015 | 105 | NLR |
AAION、 NAION | [37] | 2018 | 80 | NLR |
RVO | [39] | 2015 | 80 | NLR |
RVO | [40] | 2016 | 57 | NLR |
iERM | [51] | 2018 | 83 | NLR |
表1 NLR与其他联合检测指标在眼部疾病中的研究概况
研究病种 | 参考文献 | 时间 | 样本量 | 检测指标 |
---|---|---|---|---|
POAG | [22] | 2016 | 258 | NLR、PLR |
PXG | [23] | 2016 | 105 | NLR、PLR |
PACG | [21] | 2017 | 1 541 | NLR、LMR |
AMD | [25] | 2015 | 245 | NLR |
AMD | [44] | 2015 | 129 | NLR |
AMD | [26] | 2016 | 120 | NLR、CRP |
AMD | [28] | 2017 | 326 | NLR |
AMD | [29] | 2017 | 200 | NLR、PLR |
AMD | [45] | 2018 | 178 | NLR、PLR、MLR |
DR | [32] | 2011 | 30 973 | NLR |
DR | [46] | 2013 | 110 | NLR |
DR | [47] | 2013 | 460 | NLR |
DR | [48] | 2015 | 402 | NLR |
DR | [49] | 2015 | 114 | NLR |
DR | [50] | 2015 | 188 | NLR、MLR |
DED | [36] | 2018 | 65 | NLR、CRP |
DED | [35] | 2016 | 138 | NLR |
AAION | [38] | 2015 | 105 | NLR |
AAION、 NAION | [37] | 2018 | 80 | NLR |
RVO | [39] | 2015 | 80 | NLR |
RVO | [40] | 2016 | 57 | NLR |
iERM | [51] | 2018 | 83 | NLR |
[1] | KRUGER P,SAFFARZADEH M,WEBER A N,et al.Neutrophils:between host defence,immune modulation,and tissue injury[J]. PLoS Pathog,2015,11(3):e1004651. |
[2] | PILLAY J,KAMP V M,VAN HOFFEN E,et al.A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1[J]. J Clin Invest,2012,122(1):327-336. |
[3] | FARIA S S,FERNANDES P C Jr,SILVA M J,et al. The neutrophil-to-lymphocyte ratio:a narrative review[J]. Ecancermedicalscience,2016,10:702. |
[4] | WILLIAMS P A,MARSH-ARMSTRONG N,HOWELL G R,et al.Neuroinflammation in glaucoma:a new opportunity[J]. Exp Eye Res,2017,157:20-27. |
[5] | RATAY M L,BELLOTTI E,GOTTARDI R,et al.Modern therapeutic approaches for noninfectious ocular diseases involving inflammation[J]. Adv Healthc Mater,2017,6(23). |
[6] | DEHDASHTIAN E,MEHRZADI S,YOUSEFI B,et al.Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin;involvement of autophagy,inflammation and oxidative stress[J]. Life Sci,2018,193:20-33. |
[7] | ZENKEL M,LEWCZUK P,JÜNEMANN A,et al. Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome/glaucoma[J]. Am J Pathol,2010,176(6):2868-2879. |
[8] | VUJOSEVIC S,SIMÓ R. Local and systemic inflammatory biomarkers of diabetic retinopathy:an integrative approach[J]. Invest Ophthalmol Vis Sci,2017,58(6):BIO68-BIO75. |
[9] | REZAR-DREINDL S,SACU S,EIBENBERGER K,et al.The intraocular cytokine profile and therapeutic response in persistent neovascular age-related macular degeneration[J]. Invest Ophthalmol Vis Sci,2016,57(10):4144-4150. |
[10] | COUGHLIN B,SCHNABOLK G,JOSEPH K,et al.Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and γδ T-cells[J]. Sci Rep,2016,6:23794. |
[11] | SWIERCZAK A,MOUCHEMORE K A,HAMILTON J A,et al.Neutrophils:important contributors to tumor progression and metastasis[J]. Cancer Metastasis Rev,2015,34(4):735-751. |
[12] | PROCTOR M J,MCMILLAN D C,MORRISON D S,et al.A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer[J]. Br J Cancer,2012,107(4):695-699. |
[13] | 马晓路,吴炯,周琰,等. 术前中性粒细胞/淋巴细胞比值对肝细胞肝癌根治性切除术后肿瘤早期复发的影响[J]. 检验医学,2016,31(10):863-868. |
[14] | 赵卫卫,肖林林,刘秀芬,等. 术前外周血中性粒细胞/淋巴细胞比值在乳腺癌诊断中的作用[J]. 检验医学,2018,33(3):209-212. |
[15] | TEMPLETON A J,MCNAMARA M G,ŠERUGA B,et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors:a systematic review and meta-analysis[J]. J Natl Cancer Inst,2014,106(6):dju124. |
[16] | ANGKANANARD T,ANOTHAISINTAWEE T,MCEVOY M,et al.Neutrophil lymphocyte ratio and cardiovascular disease risk:a systematic review and meta-analysis[J]. Biomed Res Int,2018,2018:2703518. |
[17] | BHAT T,TELI S,RIJAL J,et al.Neutrophil to lymphocyte ratio and cardiovascular diseases:a review[J]. Expert Rev Cardiovasc Ther,2013,11(1):55-59. |
[18] | CHANDRASHEKARA S,MUKHTAR AHMAD M,RENUKA P,et al.Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis[J]. Int J Rheum Dis,2017,20(10):1457-1467. |
[19] | WU Y,CHEN Y,YANG X,et al.Neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) were associated with disease activity in patients with systemic lupus erythematosus[J]. Int Immunopharmacol,2016,36:94-99. |
[20] | 戴毅,孙兴怀. 从流行病学角度认识青光眼的特点与危害[J]. 中国眼耳鼻喉科杂志,2016,16(3):179-181. |
[21] | LI S,CAO W,HAN J,et al.The diagnostic value of white blood cell,neutrophil,neutrophil-to-lymphocyte ratio,and lymphocyte-to-monocyte ratio in patients with primary angle closure glaucoma[J]. Oncotarget,2017,8(40):68984-68995. |
[22] | OZGONUL C,SERTOGLU E,MUMCUOGLU T,et al.Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as novel biomarkers of primary open-angle glaucoma[J]. J Glaucoma,2016,25(10):e815-e820. |
[23] | OZGONUL C,SERTOGLU E,MUMCUOGLU T,et al.Prediction of pseudoexfoliation syndrome and pseudoexfoliation glaucoma by using neutrophil to lymphocyte ratio and platelet to lymphocyte ratio[J]. Ocul Immunol Inflamm,2016,24(6):665-670. |
[24] | SINGH A,SUBHI Y,KROGH NIELSEN M,et al.Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration:a case-control study[J]. Sci Rep,2017,7(1):605. |
[25] | ILHAN N,DAGLIOGLU M C,ILHAN O,et al.Assessment of neutrophil/lymphocyte ratio in patients with age-related macular degeneration[J]. Ocul Immunol Inflamm,2015,23(4):287-290. |
[26] | KURTUL B E,OZER P A.The relationship between neutrophil-to-lymphocyte ratio and age-related macular degeneration[J]. Korean J Ophthalmol,2016,30(5):377-381. |
[27] | NIAZI S,KROGH NIELSEN M,SØRENSEN T L,et al. Neutrophil-to-lymphocyte ratio in age-related macular degeneration:a systematic review and meta-analysis[J]. Acta Ophthalmol,2019,97(6):558-566. |
[28] | SUBHI Y,LYKKE SØRENSEN T. New neovascular age-related macular degeneration is associated with systemic leucocyte activity[J]. Acta Ophthalmol,2017,95(5):472-480. |
[29] | SENGUL E A,ARTUNAY O,KOCKAR A,et al.Correlation of neutrophil/lymphocyte and platelet/lymphocyte ratio with visual acuity and macular thickness in age-related macular degeneration[J]. Int J Ophthalmol,2017,10(5):754-759. |
[30] | FUJITA T,HEMMI S,KAJIWARA M,et al.Complement-mediated chronic inflammation is associated with diabetic microvascular complication[J]. Diabetes Metab Res Rev,2013,29(3):220-226. |
[31] | FAWWAD A,BUTT A M,SIDDIQUI I A,et al.Neutrophil-to-lymphocyte ratio and microvascular complications in subjects with type 2 diabetes:Pakistan's perspective[J]. Turk J Med Sci,2018,48(1):157-161. |
[32] | WOO S J,AHN S J,AHN J,et al.Elevated systemic neutrophil count in diabetic retinopathy and diabetes:a hospital-based cross-sectional study of 30 793 Korean subjects[J]. Invest Ophthalmol Vis Sci,2011,52(10):7697-7703. |
[33] | LIU J,LIU X,LI Y,et al. The association of neutrophil to lymphocyte ratio,mean platelet volume,and platelet distribution width with diabetic retinopathy and nephropathy:a meta-analysis[J]. Biosci Rep,2018,38(3):BSR20180172. |
[34] | LUO W J,ZHANG W F.The relationship of blood cell-associated inflammatory indices and diabetic retinopathy:a Meta-analysis and systematic review[J]. Int J Ophthalmol,2019,12(2):312-323. |
[35] | SEKERYAPAN B,UZUN F,BUYUKTARAKCI S,et al.Neutrophil-to-lymphocyte ratio increases in patients with dry eye[J]. Cornea,2016,35(7):983-986. |
[36] | CELIK T.Assessment of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with dry eye disease[J]. Ocul Immunol Inflamm,2018,26(8):1219-1222. |
[37] | INANC M,TEKIN K,BUDAKOGLU O,et al.Could platelet indices and neutrophil to lymphocyte ratio be new biomarkers for differentiation of arteritic anterior ischemic neuropathy from non-arteritic type?[J]. Neuroophthalmology,2018,42(5):287-294. |
[38] | POLAT O,YAVA G F,NAN S,et al.Neutrophil-to-lymphocyte ratio as a marker in patients with non-arteritic anterior ischemic optic neuropathy[J]. Balkan Med J,2015,32(4):382-387. |
[39] | DURSUN A,OZTURK S,YUCEL H,et al.Association of neutrophil/lymphocyte ratio and retinal vein occlusion[J]. Eur J Ophthalmol,2015,25(4):343-346. |
[40] | TURKSEVEN KUMRAL E,YENEREL N M,ERCALIK N Y,et al.Neutrophil/lymphocyte ratio and mean platelet volume in branch retinal vein occlusion[J]. Saudi J Ophthalmol,2016,30(2):105-108. |
[41] | DIKKAYA F,KARAMAN ERDUR S,OZSUTCU M,et al.The significance of neutrophil-to-lymphocyte ratio in idiopathic epiretinal membrane[J]. Int Ophthalmol,2018,38(4):1393-1397. |
[42] | ZORENA K,MYLIWSKA J,MYLIWIEC M,et al.Serum TNF-alpha level predicts nonproliferative diabetic retinopathy in children[J]. Mediators Inflamm,2007,2007:92196. |
[43] | COSTAGLIOLA C,ROMANO V,DE TOLLIS M,et al.TNF-alpha levels in tears:a novel biomarker to assess the degree of diabetic retinopathy[J]. Mediators Inflamm,2013,2013:629529. |
[44] | LECHNER J,CHEN M,HOGG R E,et al.Alterations in circulating immune cells in neovascular age-related macular degeneration[J]. Sci Rep,2015,5:16754. |
[45] | PINNA A M,PORCU T M,D'AMICO-RICCI G M,et al. Complete blood cell count-derived inflammation biomarkers in men with age-related macular degeneration[J]. Ocul Immunol Inflamm,2019,27(6):932-936. |
[46] | ULU S M,DOGAN M,AHSEN A,et al.Neutrophil-to-lymphocyte ratio as a quick and reliable predictive marker to diagnose the severity of diabetic retinopathy[J]. Diabetes Technol Ther,2013,15(11):942-947. |
[47] | ÖZTÜRK Z A,KUYUMCU M E,YESIL Y,et al. Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients?[J]. J Endocrinol Investi,2013,36(8):593-599. |
[48] | WANG R T,ZHANG J R,LI Y,et al.Neutrophil-lymphocyte ratio is associated with arterial stiffness in diabetic retinopathy in type 2 diabetes[J]. J Diabetes Complications,2015,29(2):245-249. |
[49] | CIRAY H,AKSOY A H,ULU N,et al.Nephropathy,but not angiographically proven retinopathy,is associated with neutrophil to lymphocyte ratio in patients with type 2 diabetes[J]. Exp Clin Endocrinol Diabetes,2015,123(5):267-271. |
[50] | YUE S,ZHANG J,WU J,et al.Use of the monocyte-to-lymphocyte ratio to predict diabetic retinopathy[J]. Int J Environ Res Public Health,2015,12(8):10009-10019. |
[51] | DIKKAYA F,KARAMAN ERDUR S,OZSUTCU M,et al.The significance of neutrophil-to-lymphocyte ratio in idiopathic epiretinal membrane[J]. Int Ophthalmol,2018,38(4):1393-1397. |
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