孕妇血清性激素、IGF-1与25（OH）D的关系

doi:10.3969/j.issn.1673-8640.2017.011.007

摘要/Abstract

摘要：

目的探讨孕期妇女血清性激素及胰岛素生长因子1（IGF-1）与25-羟基维生素D[25（OH）D]之间的关系。方法用随机抽样法抽取362名孕早期孕妇作为实验组,同时纳入与实验组年龄、抽样时间相匹配的未孕妇女136名作为对照组。将受试者根据抽样所处季节分组：1—6月抽样的受试者被纳入第1组,其中实验组Ⅰ125名、对照组Ⅰ62名;7—12月抽样的受试者被纳入第2组,其中实验组Ⅱ237名、对照组Ⅱ74名。用相关性和线性回归模型分析性激素、IGF-1和25（OH）D三者之间的关系。结果不同月份25（OH）D水平有一定差异,其在4月时最低[（24.1±7.9）nmol/L],在8月时最高[（50.2±8.3）nmol/L],实验组Ⅰ与实验组Ⅱ间25（OH）D水平差异具有统计学意义（P=0.006）。经产妇的血清25（OH）D水平[（39.7±8.4）nmol/L]显著高于初产妇[（30.8±7.9）nmol/L,P=0.013];实验组25（OH）D、雌二醇、孕酮和17-羟孕酮（17-OHP）水平显著高于对照组（P<0.05）,睾酮、雄烯二酮和IGF-1 2组间差异无统计学意义（P>0.05）;25（OH）D的水平与生育次数存在弱相关性（r=0.21,P=0.04）;25（OH）D水平与性激素及IGF-1间的相关性较弱;当血清25（OH） D的水平增加1 IU时,雌二醇的水平减少7.9%。在不同25（OH）D水平组的孕妇间,各性激素及IGF-1水平差异无统计学意义（P>0.05）。结论孕早期血清25（OH）D水平与性激素或IGF-1的水平间不存在相关性。

关键词: 25-羟基维生素D, 雌二醇, 性激素, 胰岛素生长因子1, 孕早期

Abstract:

Objective To investigate the relationship of maternal sex hormones,insulin-like growth factor-1（IGF-1） and 25-hydroxyvitamin D [25（OH）D] in serum during pregnancy. Methods By random method,362 pregnant women in the first trimester of pregnancy were enrolled as experimental group,and 136 non-pregnant women were enrolled as control group with similar age and blood extraction time. All participants were subclassified according to season of blood extraction. The first group was from January to June（125 cases of experimental groupⅠ and 62 cases of control groupⅠ）,and the second group was from July to December（237 cases of experimental groupⅡ and 74 cases of control groupⅡ）. Correlation and linear regression models were used to assess the relations of maternal sex hormones,IGF-1 and 25（OH）D. Results Serum 25（OH）D levels in different months had difference,the lowest level was in April [（24.1±7.9）nmol/ L],and the highest level was in August [（50.2±8.3）nmol/L]. There was statistical significance between experimental groupⅠand experimental group Ⅱ（P=0.006）. Serum 25（OH）D level in multiparous women [（39.7±8.4）nmol/L] was higher than that in primiparous women [（30.8±7.9）nmol/L,P=0.013]. Serum 25（OH）D,estradiol,progesterone and 17-hydroxyprogesterone（17-OHP） levels were higher in experimental group than those in control group. There was no statistical significance for testosterone,rostenedione and IGF-1 between experimental and control groups（P>0.05）. Serum 25（OH）D levels and multiparous times had weakly positive correlation（r=0.21,P=0.04）. Serum 25（OH）D levels and maternal sex hormones,IGF-1 had weak correlation. When serum 25（OH）D levels increased by 1 IU,the levels of estradiol decreased by 7.9%. For different levels of 25（OH）D,maternal sex hormones and IGF-1 of pregnant women had no statistical significance（P>0.05）. Conclusions There is no correlation between maternal sex hormones and IGF-1 during the first trimester of pregnancy.

Key words: 25-Hydroxyvitamin D, Estradiol, Sex hormone, Insulin-like growth factor-1, The first trimester of pregnancy

中图分类号:

R446.62

王娟, 李引弟. 孕妇血清性激素、IGF-1与25（OH）D的关系[J]. 检验医学, 2017, 32(11): 970-974.

WANG Juan, LI Yindi. Relationship of maternal sex hormones,IGF-1 and 25（OH）D in serum during pregnancy[J]. Laboratory Medicine, 2017, 32(11): 970-974.

图/表 2

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组别	年龄（岁）	25（OH）D（nmol/L）	雌二醇（ng/mL）	孕酮（ng/mL）	17-OHP（ng/mL）	睾酮（ng/mL）	雄烯二酮（ng/mL）	IGF-1 （μg/mL）
第1组
实验组Ⅰ	31.8±4.0	34.8±8.6	6.32±2.80	35.90±5.30	2.57±1.00	1.29±0.70	3.69±0.70	172.3±12.9
对照组Ⅰ	30.2±4.9	31.6±7.2	0.22±0.10	16.90±7.20	1.02±0.80	1.38±0.50	2.62±0.90	183.4±13.4
P值	0.735	0.032	<0.001	<0.001	0.038	0.582	0.136	0.358
第2组
实验组Ⅱ	30.6±2.7	39.4±9.2	6.28±3.20	34.90±6.80	2.56±0.90	1.28±0.50	3.72±0.80	169.8±13.4
对照组Ⅱ	31.1±3.2	34.6±8.3	0.23±0.20	17.60±7.60	0.96±0.60	1.36±0.70	2.49±1.20	159.4±16.9
P值	0.681	0.045	<0.001	<0.001	0.047	0.657	0.145	0.426

组别	年龄（岁）	25（OH）D（nmol/L）	雌二醇（ng/mL）	孕酮（ng/mL）	17-OHP（ng/mL）	睾酮（ng/mL）	雄烯二酮（ng/mL）	IGF-1 （μg/mL）
第1组
实验组Ⅰ	31.8±4.0	34.8±8.6	6.32±2.80	35.90±5.30	2.57±1.00	1.29±0.70	3.69±0.70	172.3±12.9
对照组Ⅰ	30.2±4.9	31.6±7.2	0.22±0.10	16.90±7.20	1.02±0.80	1.38±0.50	2.62±0.90	183.4±13.4
P值	0.735	0.032	<0.001	<0.001	0.038	0.582	0.136	0.358
第2组
实验组Ⅱ	30.6±2.7	39.4±9.2	6.28±3.20	34.90±6.80	2.56±0.90	1.28±0.50	3.72±0.80	169.8±13.4
对照组Ⅱ	31.1±3.2	34.6±8.3	0.23±0.20	17.60±7.60	0.96±0.60	1.36±0.70	2.49±1.20	159.4±16.9
P值	0.681	0.045	<0.001	<0.001	0.047	0.657	0.145	0.426

组别	例数	雌二醇（ng/mL）	孕酮（ng/mL）	17-OHP （ng/mL）	睾酮（ng/mL）	雄烯二酮（ng/mL）	IGF-1 （μg/mL）
25（OH）D低水平组	164	6.35±2.34	35.70±5.69	2.77±1.04	1.24±0.71	3.67±0.67	172.5±11.6
25（OH）D高水平组	198	6.27±2.17	36.20±4.95	2.45±0.96	1.38±0.64	3.73±0.72	183.6±13.5
P值		0.37	0.74	0.63	0.26	0.95	0.35

组别	例数	雌二醇（ng/mL）	孕酮（ng/mL）	17-OHP （ng/mL）	睾酮（ng/mL）	雄烯二酮（ng/mL）	IGF-1 （μg/mL）
25（OH）D低水平组	164	6.35±2.34	35.70±5.69	2.77±1.04	1.24±0.71	3.67±0.67	172.5±11.6
25（OH）D高水平组	198	6.27±2.17	36.20±4.95	2.45±0.96	1.38±0.64	3.73±0.72	183.6±13.5
P值		0.37	0.74	0.63	0.26	0.95	0.35