关键词: P选择素, 白细胞介素6, 高敏C反应蛋白, 类风湿性关节炎

Abstract:

Objective To investigate the changes and roles of cluster of differentiation 62 platelet（CD62p）,interleukin 6（IL-6） and high-sensitivity C-reactive protein（hs-CRP） levels in patients with rheumatoid arthritis（RA）. Methods A total of 50 healthy subjects were enrolled as healthy control group,and 60 patients with osteoarthritis were enrolled as disease control group. A total of 125 patients with RA were classified into 3 sub-groups,high active group（35 cases）,active group（42 cases） and remission group（48 cases）. The positive rate of CD62p and the levels of IL-6 and hs-CRP were determined. Results Compared with healthy control group,the positive rate of CD62p and the levels of IL-6 and hs-CRP were higher in RA group（P<0.01）,those were higher in high active group than those in active group and remission group（P<0.05）,and the positive rate and the levels were higher in active group than those in remission group（P<0.01）. Totally,among 52 cases in high active and active groups who can be followed up,49 cases had effective treatment. The positive rate of CD62p and the levels of IL-6 and hs-CRP decreased after treatment for 6 months（P<0.01）. After treatment for 12 months,the positive rate of CD62p and the level of hs-CRP decreased compared with those for 6 months（P<0.01）. The positive rate of CD62p and the level of hs-CRP had negative correlations with disease activity score 28（DAS28）（r=0.325 and 0.547,P<0.05）. The positive rate of CD62p and the levels of IL-6 and hs-CRP had positive correlations（r=0.450 and 0.539,P<0.01）. Conclusions The positive rate of CD62p and the levels of IL-6 and hs-CRP in patients with RA reflect the different states of disease,and they may provide a reference for the diagnosis and treatment of RA.

Key words: Cluster of differentiation 62 platelet, Interleukin 6, High-sensitivity C-reactive protein, Rheumatoid arthritis