检验医学 ›› 2017, Vol. 32 ›› Issue (11): 975-978.DOI: 10.3969/j.issn.1673-8640.2017.011.008

• 临床应用研究_论著 • 上一篇    下一篇

抗CCP抗体和抗MCV抗体等多种检测对类风湿性关节炎的诊断价值

赵万辉, 王泽筠, 亓琳, 耿丽丽, 张璐璐, 刘义庆, 许瑞   

  1. 山东大学附属省立医院临床医学检验部, 山东 济南 250021
  • 收稿日期:2016-11-28 出版日期:2017-11-30 发布日期:2017-12-07
  • 作者简介:null

    作者简介：赵万辉,女,1987年生,学士,技师,主要从事免疫学研究。

  • 基金资助:
    山东省自然科学基金项目（ZR2014HP043）;山东省临床重点专科建设项目（鲁卫医字[2013]26号）

Determinations of anti-CCP antibody and anti-MCV antibody for the diagnosis of rheumatoid arthritis

ZHAO Wanhui, WANG Zejun, QI Lin, GENG Lili, ZHANG Lulu, LIU Yiqing, XU Rui   

  1. Department of Clinical Laboratory,Shandong Provincial Hospital,Shandong University,Jinan 250021,Shandong,China
  • Received:2016-11-28 Online:2017-11-30 Published:2017-12-07

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摘要：

目的 探讨抗环瓜氨酸多肽（CCP）抗体、抗类风湿性关节炎蛋白33（RA33）抗体、抗葡萄糖6磷酸异构酶（GPI）抗体、抗突变型瓜氨酸波形蛋白（MCV）抗体、类风湿因子（RF）及其亚型、红细胞沉降率（ESR）对类风湿性关节炎（RA）的临床诊断价值。方法 选取经临床确诊的RA患者165例、非RA结缔组织病患者120例、体检健康者80名,分别检测其血清抗CCP抗体、抗RA33抗体、抗GPI抗体、抗MCV抗体、RF-IgA、RF-IgG、RF-IgM、RF及ESR水平,并对结果进行统计分析。结果 诊断RA的敏感性分别为抗CCP抗体85.4%、抗RA33抗体11.0%、抗GPI抗体67.2%、抗MCV抗体84.0%、RF-IgA 82.4%、RF-IgG 17.0%、RF-IgM 83.6%、RF 87.8%、ESR 81.8%,特异性分别为抗CCP抗体95.0%、抗RA33抗体98.3%、抗GPI抗体83.3%、抗MCV抗体90.0%、RF-IgA 91.6%、RF-IgG 95.8%、RF-IgM 70.8%、RF 83.3%、ESR 70.8%。抗CCP抗体和抗MCV抗体联合检测的敏感性和特异性分别为98.8%和96.7%。结论 抗CCP抗体和抗MCV抗体是对RA有较高诊断价值的血清学标志物,与抗RA33抗体、抗GPI抗体、RF-IgA、RF-IgG、RF-IgM、RF及ESR的检测结果相结合,可提高对RA的诊断率,有助于RA的临床诊断。

关键词: 抗环瓜氨酸多肽抗体, 抗类风湿性关节炎蛋白33抗体, 抗葡萄糖6磷酸异构酶抗体, 抗突变型瓜氨酸波形蛋白抗体, 类风湿因子, 红细胞沉降率, 类风湿性关节炎

Abstract:

Objective To investigate the roles of anti-cyclic citrullinated peptide（CCP） antibody,anti-rheumatoid arthritis 33（RA33） antibody,anti-glucose-6-phosphate isomerase（GPI） antibody,anti-mutated citrullinated vimentin（MCV） antibody,rheumatoid factor（RF）,RF subtypes and erythrocyte sedimentation rate（ESR）for the diagnosis of rheumatoid arthritis（RA）. Methods A total of 165 patients with RA and 120 patients with mixed connective tissue disease were enrolled. A total of 80 healthy subjects were enrolled as healthy control group. Serum anti-CCP,anti-RA33,anti-GPI and anti-MCV antibodies,RF-IgA,RF-IgG,RF-IgM,RF and ESR were determined. Results The sensitivities of anti-CCP,anti-RA33,anti-GPI and anti-MCV antibodies,RF-IgA,RF-IgG,RF-IgM,RF and ESR in RA group were 85.4%,11.0%,67.2%,84.0%,82.4%,17.0%,83.6%,87.8% and 81.8%,respectively. Their specificities were 95.0%,98.3%,83.3%,90.0%,91.6%,95.8%,70.8%,83.3% and 70.8%,respectively. The sensitivity and specificity of the combined determination of anti- CCP antibody and anti-MCV antibody were 98.8% and 96.7% in RA group. Conclusions Anti-CCP and anti-MCV antibodies can be biomarkers for the diagnosis of RA. Combining the results of anti-RA33 and anti-GPI antibodies,RF-IgA,RF-IgG,RF-IgM,RF and ESR,the diagnosis of RA can be improved.

Key words: Anti-cyclic citrullinated peptide antibody, Anti-rheumatoid arthritis 33 antibody, Anti-glucose-6-phosphate isomerase antibody, Anti-mutated citrullinated vimentin antibody, Rheumatoid factor, Erythrocyte sedimentation rate, Rheumatoid arthritis

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