关键词: 25-羟基维生素D, C反应蛋白, 慢性阻塞性肺疾病, 急性加重

Abstract:

Objective To investigate serum 25-hydroxyvitamin D [25（OH）D] determination in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods The levels of serum 25（OH）D and C-reactive protein（CRP） were determined in 72 patients with chronic obstructive pulmonary disease（COPD）（44 cases of AECOPD and 28 cases of remission of COPD） and 36 healthy subjects（healthy control group）by electrochemiluminescence and turbidimetry immunoassay. Results The level of serum 25（OH）D in AECOPD group [（14.9±5.9）ng/mL] was lower than those in COPD remission group [（20.8±8.0）ng/mL] and healthy control group [（23.9±8.6）ng/mL]（P<0.05）. However,there was no statistical significance for serum 25（OH）D between COPD remission group and healthy control group（P>0.05）. The level of serum CRP in AECOPD group [（44.5±13.3）mg/L] was higher than those in COPD remission group [（8.72±2.76）mg/L] and healthy control group [（2.68±1.72）mg/L]（P<0.05）. The level of serum CRP in COPD remission group was higher than that in healthy control group（P<0.05）. Conclusions The deficiency of serum 25（OH）D may be one of risk factors for AECOPD patients. The supplementation of 25（OH）D may have a preventive effect on AECOPD.

Key words: 25-Hydroxyvitamin D, C-reactive protein, Chronic obstructive pulmonary disease, Acute exacerbation