检验医学 ›› 2015, Vol. 30 ›› Issue (10): 980-982.DOI: 10.3969/j.issn.1673-8640.2015.10.003

• 临床应用研究·论著 • 上一篇    下一篇

血清降钙素原定量检测在细菌感染诊断中的临床意义

黄晨静, 夏华峰, 王寅   

  1. 浙江中医药大学附属第二医院检验科,浙江 杭州 310005
  • 收稿日期:2015-06-17 出版日期:2015-10-30 发布日期:2015-11-04
  • 作者简介:null

    作者简介:黄晨静,女,1978年生,学士,技师,主要从事临床微生物检验工作。

    通讯作者:王 寅,联系电话:0571-85267163。

  • 基金资助:
    浙江省中医药科学研究基金资助项目(2011ZB056)

Clinical application of the quantitative determination of serum procalcitonin in the diagnosis of bacterial infection

HUANG Chenjing, XIA Huafeng, WANG Yin.   

  1. Department of Clinical Laboratory, the Second Affiliated Hospital to Zhejiang Traditional Chinese Medical University, Zhejiang Hangzhou 310005, China
  • Received:2015-06-17 Online:2015-10-30 Published:2015-11-04

摘要: 目的

了解血清降钙素原(PCT)定量检测在不同病原体(细菌与非细菌、革兰阳性球菌与革兰阴性杆菌)、不同类型(全身感染与呼吸系统、泌尿系统等局部感染)、不同人群(男性与女性、不同年龄段)感染的临床应用价值。

方法

分离鉴定从2014年1至12月间住院或门诊疑似感染患者送检样本中的细菌和真菌,同时采用定量方法检测患者的血清PCT水平,并进行统计学分析。

结果

血清PCT水平在细菌感染组中升高显著,而在真菌及非细菌感染组中升高不明显,二者间差异有统计学意义(P<0.05);细菌全身感染组PCT水平明显高于细菌局部感染组(P<0.05);在细菌局部感染中,呼吸系统、泌尿系统和神经系统感染组间血清PCT水平差异无统计学意义(P> 0.05)。在细菌感染中,革兰阴性杆菌感染患者血清PCT水平高于革兰阳性球菌感染患者(P<0.05);男性与女性细菌感染患者之间血清PCT水平差异无统计学意义(P> 0.05),各年龄组之间差异亦无统计学意义(P> 0.05)。

结论

PCT可作为细菌感染尤其是全身感染的重要指标。

关键词: 降钙素原, 细菌, 真菌, 全身感染, 局部感染, 革兰阴性杆菌, 革兰阳性球菌, 性别, 年龄

Abstract: Objective

To evaluate the clinical application significance of serum procalcitonin (PCT) quantitative detemination in the diagnosis of different pathogens (bacterium and non-bacterium, Gram-positive coccus and Gram-negative bacillus), different types (systemic infection and local infection such as urinary and respiratory systems), different populations (male, female and different age groups).

Methods

The pathogens were isolated from outpatients and inpatients from January 2014 to December 2014, meanwhile serum PCT was determined quantitatively, and the results were analyzed statistically.

Results

The serum PCT in bacterium infection group was significantly higher than those in fungus and non-bacterium infection groups, and the difference was statistically significant (P<0.05). The serum PCT in systemic infection group was significantly higher than that in local infection group (P<0.05). There was no statistical significance for serum PCT levels among bacterium infection, respiratory system, urinary system and nervous system infection groups (P> 0.05). In bacterium infection group, serum PCT level in Gram-negative bacillus infection group was higher than that in Gram-positive coccus infection group (P<0.05). However, there was no statistical significance between male and female and for different ages(P>0.05).

Conclusions

Serum PCT can be used as an important indicator of bacterium infection, especially systemic infection.

Key words: Procalcitonin, Bacterium, Fungus, Systemic infection, Local infection, Gram-nagative bacillus, Gram-positive coccus, Sex, Age

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