侵袭性真菌感染实验室诊断研究进展

doi:10.3969/j.issn.1673-8640.2023.02.016

检验医学 ›› 2023, Vol. 38 ›› Issue (2): 179-185.DOI: 10.3969/j.issn.1673-8640.2023.02.016

侵袭性真菌感染实验室诊断研究进展

王东江综述, 郭建审核

同济大学附属东方医院南院医学检验科，上海 200123

收稿日期:2021-08-31 修回日期:2022-05-26 出版日期:2023-02-28 发布日期:2023-04-17
通讯作者: 郭建，E-mail：guojian1110@126.com。
作者简介:王东江，男，1982年生，主管技师，主要从事临床微生物检验工作。
基金资助:
国家自然科学基金项目(81971990);上海市公共卫生体系重点学科基金项目(GWV-10.1-XK04);上海市优秀技术带头人基金项目(20XD1434500)

Advance in laboratory diagnosis of invasive fungal infection

WANG Dongjiang, GUO Jian

Department of Clinical Laboratory，South Campus，Shanghai East Hospital，Tongji University，Shanghai 200123，China

Received:2021-08-31 Revised:2022-05-26 Online:2023-02-28 Published:2023-04-17

摘要/Abstract

摘要：

侵袭性真菌感染的发病率、死亡率和治疗费用均较高，且具有与其他病原感染相似的临床表现，极易造成误诊，正确诊断至关重要。准确诊断和合理使用抗真菌药物是临床治疗侵袭性真菌感染的关键。文章从真菌培养和鉴定、抗原和抗体检测、分子生物学检测技术等方面对侵袭性真菌感染实验室诊断的研究进展进行综述。

关键词: 侵袭性真菌, 感染, 念珠菌, 隐球菌, 曲霉菌, 诊断

Abstract:

Invasive fungal infection has high morbidity and mortality with high cost of treatment，so the diagnosis of invasive fungal infection is important. Invasive fungal infection has similar clinical manifestations as other infections，and it is prone to misdiagnosis. There is an urgent need to improve the accurate diagnosis and treatment of invasive fungal infection. This review mainly introduces the development of clinical laboratory diagnosis of invasive fungal infection from the aspects of fungal culture and identification，antigen and antibody determinations and molecular biological determination.

Key words: Invasive fungus, Infection, Candida, Cryptococcus, Aspergillus, Diagnosis

中图分类号:

R446.1

王东江, 郭建. 侵袭性真菌感染实验室诊断研究进展[J]. 检验医学, 2023, 38(2): 179-185.

WANG Dongjiang, GUO Jian. Advance in laboratory diagnosis of invasive fungal infection[J]. Laboratory Medicine, 2023, 38(2): 179-185.

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侵袭性真菌感染实验室诊断研究进展

Advance in laboratory diagnosis of invasive fungal infection

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