A total of 155 sepsis patients, 56 patients with non-sepsis (infection group) and 43 non-infected controls were enrolled, and their platelet (PLT), procalcitonin (PCT), C reactive protein (CRP), white blood cell (WBC), the percentage of neutrophils (NE) and Bcl-xL protein levels were determined. The results were analyzed statistically. Blood culture was performed simultaneously, 75 cases of blood culture-positive sepsis patients were classified into G⁺ and G^- groups. Their PLT, PCT, Bcl-xL protein and different PCT cross-section percentages were analyzed.

Biochemical parameters of sepsis group had obvious difference with those of control group (P<0.01). Compared with infection group, serum PLT, PCT, CRP and Bcl-xL protein levels were significantly different (P<0.01), and WBC and the percentage of NE had no statistical significance (P> 0.05). In infection group, PCT, CRP, WBC, NE percentage had statistical significance compared with those in control group (P<0.01), but the differences of PLT and Bcl-xL protein were not significant (P> 0.05). For G⁺ and G^- groups in sepsis patients, when PCT <2.0 ng/mL, there was no statistical significance (P>0.05). When 2.0 ng/mL≤PCT≤10.0 ng/mL, the percentage in G⁺ group was significantly higher than that in G^- group (P<0.01). When PCT ≥ 10.0 ng/mL, the percentage in G^- group was significantly higher than that in G⁺ group (P<0.01). PLT and PCT levels in G^- group were lower than those in G⁺ group (P<0.01).

The reduction of PLT and the increase of PCT are related to the apoptosis of PLT caused by Bcl-xL protein. G^- sepsis is easier to start PLT apoptosis than G⁺ sepsis with higher risk.