网织血小板及其相关参数在儿童免疫性血小板减少症及脓毒症中的应用

doi:10.3969/j.issn.1673-8640.2018.07.011

检验医学 ›› 2018, Vol. 33 ›› Issue (7): 626-628.DOI: 10.3969/j.issn.1673-8640.2018.07.011

网织血小板及其相关参数在儿童免疫性血小板减少症及脓毒症中的应用

宋辉¹, 孔飞飞¹, 刘旋¹, 石翠明¹, 常敏¹, 完颜新蕊²

1.济宁医学院附属医院检验科,山东济宁 272000
2.济宁医学院生物科学学院,山东济宁 272029

收稿日期:2017-02-26 出版日期:2018-07-30 发布日期:2018-07-27
作者简介:null
作者简介：宋辉,男,1980年生,硕士,主管技师,主要从事出血与止血检验方面的研究。
基金资助:
济宁医学院青年基金项目（JYQ2011KM062）

Roles of reticulated platelet and related parameters in children with immunological thrombocytopenia and sepsis

SONG Hui¹, KONG Feifei¹, LIU Xuan¹, SHI Cuiming¹, CHANG Min¹, WANYAN Xinrui²

1. Department of Clinical Laboratory,Affiliated Hospital of Jining Medical University,Jining 272000,Shandong,China
2. College of Biological Sciences,Jining Medical University,Jining 272029,Shandong,China

Received:2017-02-26 Online:2018-07-30 Published:2018-07-27

摘要/Abstract

摘要：

目的探讨网织血小板（RP）及其相关参数在儿童免疫性血小板减少症（ITP）和儿童脓毒症所致血小板（PLT）降低鉴别诊断中的应用价值。方法选取临床初次确诊的儿童ITP患者（ITP组）及儿童脓毒症（脓毒症组）导致PLT降低鉴别诊断的患儿各30例、再生障碍性贫血（AA）患儿（疾病对照组）20例,以体检健康儿童30名作为正常对照组。检测所有对象网织血小板比率（RP%）、RP绝对值、平均血小板体积（MPV）、血小板分布宽度（PDW）。结果 ITP组和脓毒症组RP%、MPV、PDW明显高于正常对照组及AA组（P<0.05）,且ITP组高于脓毒症组（P<0.05）。ITP组和脓毒症组RP绝对值低于正常对照组（P<0.05）。AA组与正常对照组之间RP%、MPV、PDW差异均无统计学意义（P>0.05）。结论 RP及PLT相关参数可作为儿童ITP及儿童脓毒症导致的PLT减少患儿的鉴别诊断指标,并对患儿骨髓造血功能评估有一定意义。

关键词: 网织血小板, 网织血小板参数, 儿童免疫性血小板减少症, 儿童脓毒症

Abstract:

Objective To investigate the roles of reticulated platelet （RP） and related parameters in children with immunological thrombocytopenia （ITP） and sepsis. Methods A total of 30 newly diagnosed children with ITP,30 children with sepsis, 20 children with aplastic anemia （AA）（disease control group） and 30 healthy children （healthy control group） were enrolled. Their blood specimens were collected. Reticulated platelet ratio （RP%）,RP absolute value,mean platelet volume （MPV）,platelet distribution width （PDW） were determined. Results RP%, MPV and PDW in ITP and sepsis groups were higher than those in disease control and healthy control groups （P<0.05）, and those in ITP group were higher than those in sepsis group （P<0.05）. The RP absolute values in ITP and sepsis groups were lower than that in healthy control group （P<0.05）. There was no statistical significance for RP%, MPV and PDW between disease control and healthy control groups （P>0.05）. Conclusions The determinations of RP and platelet（PLT）related parameters can be used for the differential diagnosis of child diseases caused by ITP and sepsis. The determinations of RP and related parameters play roles in the assessment of bone marrow hematopoietic function.

Key words: Reticulated platelet, Reticulated platelet parameters, Child immunological thrombocytopenia, Child sepsis

中图分类号:

R446.1

宋辉, 孔飞飞, 刘旋, 石翠明, 常敏, 完颜新蕊. 网织血小板及其相关参数在儿童免疫性血小板减少症及脓毒症中的应用[J]. 检验医学, 2018, 33(7): 626-628.

SONG Hui, KONG Feifei, LIU Xuan, SHI Cuiming, CHANG Min, WANYAN Xinrui. Roles of reticulated platelet and related parameters in children with immunological thrombocytopenia and sepsis[J]. Laboratory Medicine, 2018, 33(7): 626-628.

图/表 1

参考文献 9

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组别	例数	RP%（%）	RP绝对值（×10⁹/L）	MPV（fL）	PDW（fL）
正常对照组	30	2.90±1.07	5.80±3.54	10.40±1.90	13.00±2.77
AA组	20	2.70±1.02	0.90±0.39	10.00±1.94	12.60±2.63
ITP组	30	16.80±4.28^*#	3.60±2.12^*#	20.00±4.63^*#	26.50±3.68^*#
脓毒症组	30	8.30±2.96^*#△	4.50±2.51^*#	14.30±2.66^*#△	18.60±3.64^*#△

组别	例数	RP%（%）	RP绝对值（×10⁹/L）	MPV（fL）	PDW（fL）
正常对照组	30	2.90±1.07	5.80±3.54	10.40±1.90	13.00±2.77
AA组	20	2.70±1.02	0.90±0.39	10.00±1.94	12.60±2.63
ITP组	30	16.80±4.28^*#	3.60±2.12^*#	20.00±4.63^*#	26.50±3.68^*#
脓毒症组	30	8.30±2.96^*#△	4.50±2.51^*#	14.30±2.66^*#△	18.60±3.64^*#△

网织血小板及其相关参数在儿童免疫性血小板减少症及脓毒症中的应用

Roles of reticulated platelet and related parameters in children with immunological thrombocytopenia and sepsis

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