The relationship of alpha2-adrenergic receptor gene polymorphism with silent myocardial ischemia in patients with type 2 diabetes mellitus

Abstract

Abstract: Objective　To investigate the relationship of alpha₂-adrenergic receptor (AR) gene polymorphisms (α_2A-AR，α_2B-AR and α_2C-AR genes) with silent myocardial ischemia (SMI) in coronary artery disease (CAD) patients with type 2 diabetes mellitus (T2DM). Methods　By polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and gene sequencing，α_2A-AR，α_2B-AR and α_2C-AR gene polymorphism analysis was performed in 107 healthy controls，129 T2DM patients with SMI and 192 T2DM patients with angina. Results　The genotype distribution and allele frequencies of α_2B-AR gene polymorphism [insertion (I)/deletion (D)］ had significant difference between SMI group and angina group (P<0.05)， with genotype I/I frequency being greatly higher in SMI group (34.9%) than in angina group (19.8%, P=0.002). Conclusions　Genotype I/I of α_2B-AR gene polymorphism is associated with SMI in CAD patients with T2DM.

Key words: Alpha₂-adrenergic receptor, Gene polymorphism, Silent myocardial ischemia, Diabetes mellitus

GAO Jing;CHEN Qiujing;ZHANG Bin;LU Lin;ZHANG Ruiyan;ZHANG Qi;HU Jian;. The relationship of alpha₂-adrenergic receptor gene polymorphism with silent myocardial ischemia in patients with type 2 diabetes mellitus[J]. , 2012, 27(9): 701-706.

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The relationship of alpha₂-adrenergic receptor gene polymorphism with silent myocardial ischemia in patients with type 2 diabetes mellitus

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