Abstract:

Objective To investigate the relationship between serum angiopoietin-like protein 7（ANGPTL7） and insulin resistance in subjects with different glucose tolerance. Methods A total of 159 patients and healthy subjects from Chu Hsien-I Memorial Hospital of Tianjin Medical University from March 2022 to December 2022 were enrolled. According to oral glucose tolerance test （OGTT），159 subjects were classified into 3 groups，normal glucose tolerance group （46 cases），impaired glucose regulation group （53 cases） and type 2 diabetes mellitus （T2DM） group （60 cases）. Blood glucose，glycated hemoglobin A_1c（HbA_1c），insulin，blood lipid，ANGPTL7 and interleukin-1 beta （IL-1β） levels were determined，and homeostasis model assessment of insulin resistance（HOMA-IR） was calculated. Pearson correlation analysis was used to evaluate the correlation among the indicators. Results The level of ANGPTL7 in T2DM group was higher than that in normal glucose tolerance group（P<0.05），but there was no statistical significance between impaired glucose regulation group and normal glucose tolerance group（P>0.05）. The IL-1β level in T2DM group was higher than those in impaired glucose regulation group and normal glucose tolerance group（P<0.05），and the IL-1β level in impaired glucose regulation group was higher than that in normal glucose tolerance group（P<0.05）. Fasting plasma glucose （FPG），fasting insulin （FINS），2 h postprandial blood glucose （2 hPG），HbA_1c，triglyceride （TG），total cholesterol （TC），high-density lipoprotein cholesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C） had statistical significance in T2DM group，impaired glucose regulation group and normal glucose tolerance group （P<0.001）. ANGPTL7 was positively correlated with FPG，FINS，2 hPG，HbA_lc，TG，IL-1β and HOMA-IR（r=0.316，0.225，0.359，0.296，0.197，0.202 and 0.260，respectively，P<0.05），and it was negatively correlated with HDL-C （r=-0.167，P<0.05）. Conclusions Serum ANGPTL7 level increases gradually with the severity of insulin resistance，and ANGPTL7 is related to the occurrence of T2DM.

Key words: Angiopoietin-like protein 7, Insulin resistance, Type 2 diabetes mellitus