Abstract:

Objective To investigate the roles of C-reactive protein/albumin ratio （CAR） and neutrophil/lymphocyte ratio （NLR） in the prediction of obstructive sleep apnea hypopnea syndrome （OSAHS） with hypertension. Methods From October 2019 to October 2022，120 patients with OSAHS in Sanya Central Hospital were enrolled and classified into hypertension group and OSAHS group according to whether they were complicated with hypertension or not during hospitalization and follow-up for 6 months after discharge. The general data were collected，and CAR and NLR were determined and calculated. Bivariate Logistic regression analysis was used to evaluate the risk factors of hypertension in OSAHS patients. Receiver operating characteristic （ROC） curve was used to evaluate the efficacy of single and combined determinations of various indicators in the prediction of OSAHS with hypertension. Results Of 120 OSAHS patients，81 cases （67.5%） were complicated with hypertension. The body mass index （BMI），NLR，CAR，diabetes mellitus history，hyperlipidemia and moderate to severe OSAHS proportion in hypertension group were higher than those in OSAHS group （P<0.05）. NLR and CAR were increased with the increase of hypertension grade of OSAHS patients （P<0.05）. Increased BMI，diabetes mellitus，hyperlipidemia，moderate to severe OSAHS，NLR and CAR were risk factors for hypertension in OSAHS patients （P<0.05）. The areas under curves （AUC） for predicting OSAHS patients with hypertension were 0.696，0.654 and 0.802，respectively，for the single and combined determinations of CAR and NLR （positive for either of the 2 indicators）. The AUC of the prediction model was 0.845. Conclusions CAR and NLR play roles in the prediction of OSAHS with hypertension，and the combined prediction model is effective in the prediction of OSAHS with hypertension.

Key words: C-reactive protein/albumin ratio, Neutrophil/lymphocyte ratio, Obstructive sleep apnea hypopnea syndrome, Hypertension