Correlation between exercise blood pressure and VCAM-1,sICAM-1 and FMD in patients with essential hypertension

doi:10.3969/j.issn.1673-8640.2021.04.012

Abstract

Abstract:

Objective To investigate the relationship between exercise blood pressure and vascular cell adhesion molecule-1（VCAM-1）,soluble intercellular cell adhesion molecule-1（sICAM-1） and flow mediated dilation（FMD） in patients with essential hypertension. Methods Serum levels of VCAM-1 and sICAM-1 were determined in 80 patients with essential hypertension and 80 healthy subjects（healthy control group）. The diastolic blood pressure of hypertensive patients（rest group）,healthy control group at rest and hypertensive patients after moderate exercise（exercise group） were measured. According to the diastolic blood pressure after exercise,the exercise group was classified into diastolic blood pressure >11.97 kPa（90 mmHg） and diastolic blood pressure≤11.97 kPa（90 mmHg） groups. Pearson correlation analysis was used to evaluate the correlation between various indicators. Results The levels of serum VCAM-1 and sICAM-1 in rest group were higher than those in healthy control group（P<0.05）. Serum VCAM-1 level in exercise group was higher than that in rest group（P<0.01）. Serum VCAM-1 and sICAM-1 in exercise group with diastolic blood pressure >11.97 kPa were higher than those with diastolic blood pressure ≤11.97 kPa（P<0.01）. The diastolic blood pressure represented FMD. The healthy control group,rest group and exercise group had negative correlations between VCAM-1 level and FMD for diastolic blood pressure≤11.97 kPa（r values were -0.24,-0.63 and -0.52,respectively,P<0.05）. In exercise group,there was no correlation between VCAM-1 level and FMD in patients >11.97 kPa（r=-0.34,P>0.05）. The level of sICAM-1 in healthy control group was positively correlated with FMD（r=0.41,P<0.01）. There was no correlation between the level of sICAM-1 and FMD in the other groups（P>0.05）. Conclusions Exercise blood pressure in patients with hypertension is closely related to VCAM-1,sICAM-1 and FMD.

Key words: Vascular cell adhesion molecule-1, Soluble intercellular cell adhesion molecule-1, Diastolic blood pressure, Exercise blood pressure, Essential hypertension

CLC Number:

R446.1

FAN Taohong, SONG Zhiming, AN Yuanyuan, LIU Luyang, DONG Fengjuan. Correlation between exercise blood pressure and VCAM-1,sICAM-1 and FMD in patients with essential hypertension[J]. Laboratory Medicine, 2021, 36(4): 404-407.

Figures/Tables 1

References 12

[1]	李治锋, 刘大标, 郭兰芳. 血管紧张素转换酶在妊娠高血压综合征早期诊断中的价值[J]. 检验医学, 2018,33(6):495-498.
[2]	左玉, 王震文, 王栋, 等. 血清MCP-1、sTREM-1、sICAM-1在肺炎患儿表达水平及其与病情严重程度的相关性分析[J]. 标记免疫分析与临床, 2019,26(7):1186-1189.
[3]	哈尼克孜·阿不都艾尼, 玛依努·玉苏甫. 维生素D结合降糖治疗对妊娠期糖尿病患者血清TLR4、VCAM-1的影响[J]. 中国妇幼保健, 2018,33(1):77-79.
[4]	曹明, 王奇军. H型高血压患者血浆同型半胱氨酸水平变化对动脉粥样硬化性疾病的影响[J]. 检验医学, 2019,34(11):1007-1010.
[5]	张德龙, 谷晓岚, 周丹, 等. 阿托伐他汀联合非洛地平对原发性高血压患者血压、肾功能及VCAM-1、HSP70的影响[J]. 国际检验医学杂志, 2019,40(9):1093-1097.
[6]	杨雪松, 孙奋勇, 李泽兵, 等. 一氧化氮、内皮素-1和同型半胱氨酸对冠心病的辅助诊断价值[J]. 检验医学, 2018,33(4):316-320.
[7]	郭艳侠, 国娟. CD4⁺CD28^-T细胞、TNF-α、VCAM-1在急性脑梗死中的意义及其与颈动脉斑块性质的相关性分析[J]. 中风与神经疾病杂志, 2020,37(1):22-27.
[8]	韩玉梅, 谢晶莹, 邓盈盈, 等. ICAM-1在NF-κB通路中表达的研究进展[J]. 西北民族大学学报(自然科学版), 2018,39(3):40-45.
[9]	黄为民, 刘时彦, 张润慧, 等. 高盐饮食对大鼠血浆AngⅡ、CGRP、ICAM-1、VCAM-1和P-S的表达的影响[J]. 昆明医科大学学报, 2015,36(11):8-11.
[10]	THAKKAR V, PATTERSON K A, STEVENS W, et al. Increased serum levels of adhesion molecules ICAM-1 and VCAM-1 in systemic sclerosis are not specific for pulmonary manifestations[J]. Clin Rheumatol, 2018,37(6):1563-1571. DOI URL PMID
[11]	崔大鹏, 王玉佳, 韩磊, 等. 胰腺组织及血清VCAM-1、ICAM-1在胰腺癌手术治疗前后的变化研究[J]. 癌症进展, 2017,159(11):1338-1341.
[12]	刘忠玉, 黄榕, 周亚丽. 可溶性细胞间黏附分子1与老年单纯收缩期高血压血管内皮功能相关[J]. 中华高血压杂志, 2013,21(10):974-978.

组别	例数	性别		年龄/岁	BMI/ （kg/m²）	VCAM-1/（μmol/L）	sICAM-1/（mg/L）
组别	例数	男/例	女/例	年龄/岁	BMI/ （kg/m²）	VCAM-1/（μmol/L）	sICAM-1/（mg/L）
正常对照组	80	48	32	65.8±3.9	22.5±5.3	11.1±0.8	0.5±0.1
静息组	45	26	19	65.5±4.4	21.9±5.7	13.4±1.7^*	0.7±0.1^*
运动组	35	23	12	66.1±5.2	23.4±6.3	14.6±1.3^#*	0.8±0.1^#*
舒张压>11.97 kPa组	15	9	6	64.9±6.3	22.9±4.7	13.9±1.3^#*	0.7±0.1^#*
舒张压≤11.97 kPa组	20	14	6	66.5±7.4	24.0±6.8	15.5±2.0^*#△	0.8±0.1^*#△

组别	例数	性别		年龄/岁	BMI/ （kg/m²）	VCAM-1/（μmol/L）	sICAM-1/（mg/L）
组别	例数	男/例	女/例	年龄/岁	BMI/ （kg/m²）	VCAM-1/（μmol/L）	sICAM-1/（mg/L）
正常对照组	80	48	32	65.8±3.9	22.5±5.3	11.1±0.8	0.5±0.1
静息组	45	26	19	65.5±4.4	21.9±5.7	13.4±1.7^*	0.7±0.1^*
运动组	35	23	12	66.1±5.2	23.4±6.3	14.6±1.3^#*	0.8±0.1^#*
舒张压>11.97 kPa组	15	9	6	64.9±6.3	22.9±4.7	13.9±1.3^#*	0.7±0.1^#*
舒张压≤11.97 kPa组	20	14	6	66.5±7.4	24.0±6.8	15.5±2.0^*#△	0.8±0.1^*#△