Correlation research on serum ferritin and homocysteine levels with carotid atherosclerosis in essential hypertension patients

doi:10.3969/j.issn.1673-8640.2015.03.005

Abstract

Abstract: Objective

To investigate the correlations of serum ferritin (SF) and homocysteine (Hcy) levels with carotid atherosclerosis (CAS)in patients with essential hypertension (EH).

Methods

SF and Hcy levels in 266 patients with EH were determined by electrochemiluminescence immunoassay and circulating enzymatic method. According to carotid intima-media thickness (CIMT, color doppler ultrasound instrument), 266 patients with EH were classified into CIMT thickening group (167 cases, CIMT>1.0 mm) and CIMT non-thickening group (99 cases, CIMT≤1.0 mm). A total of 50 healthy subjects were enrolled as control group.

Results

SF and Hcy levels in CIMT thickening group were significantly higher than those in CIMT non-thickening group(t=12.561 and 4.581, P<0.01). SF and Hcy levels in CIMT non-thickening group were higher than those in control group (t=6.305 and 2.913, P<0.01). SF and Hcy levels in CIMT thickening group were positively correlated with CIMT (r=0.597 and 0.451, P<0.01).

Conclusions

EH patients have high levels of SF and Hcy, and SF and Hcy levels are correlated to EH combined with CAS. The combined detection of SF and Hcy levels contributes to the condition and prognosis judgement.

Key words: Ferritin, Homocysteine, Carotid intima-media thickness, Carotid atherosclerosis, Essential hypertension

CLC Number:

R446.1

YANG Wendong. Correlation research on serum ferritin and homocysteine levels with carotid atherosclerosis in essential hypertension patients[J]. Laboratory Medicine, 2015, 30(3): 227-229.

Figures/Tables 1

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组别	例数	SF(ng/mL)	Hcy(mmol/L)
CIMT增厚组	167	329.5±88.3^*#	26.2±7.4^*#
CIMT非增厚组	99	197.8±42.6^*	18.9±5.1^*
正常对照组	50	117.5±22.9	12.7±3.8

组别	例数	SF(ng/mL)	Hcy(mmol/L)
CIMT增厚组	167	329.5±88.3^*#	26.2±7.4^*#
CIMT非增厚组	99	197.8±42.6^*	18.9±5.1^*
正常对照组	50	117.5±22.9	12.7±3.8