Abstract:

Objective To investigate the changes and roles of soluble suppression of tumorigenicity 2（sST2）,serum ferritin（SF） and hepcidin in patients with chronic heart failure（CHF） and anemia. Methods A total of 182 CHF patients were enrolled. According to the presence or absence of anemia,they were classified into CHF-anemia group（89 cases） and CHF-non-anemia group（93 cases）. Totally,43 healthy subjects were enrolled as healthy control group. The clinical data and laboratory determination results [fasting blood glucose（FBG）,C-reactive protein（CRP）,N-terminal pro-B-type natriuretic peptide（NT-proBNP）,hemoglobin（Hb）,hematocrit（HCT） and serum iron] were collected. The levels of sST2,SF and hepcidin were determined. The correlations were evaluated by Pearson correlation analysis. The risk factors of CHF combined with anemia were evaluated by Logistic regression analysis. The diagnostic role of each index for CHF combined with anemia was evaluated by receiver operating characteristic（ROC） curve. Results The levels of CRP,NT-proBNP and sST2 in CHF-anemia group and CHF-non-anemia group were higher than those in healthy control group（P<0.05）. The levels of CRP,NT-proBNP,sST2 and hepcidin in CHF-anemia group were higher than those in CHF-non-anemia group（P<0.05）,while the levels of Hb,serum iron and SF were lower（P<0.05）. Logistic regression analysis showed that the increased levels of CRP,NT-proBNP,sST2 and hepcidin were risk factors for CHF combined with anemia（P<0.05）,while the increased levels of Hb,HCT,serum iron and SF were protective factors（P<0.05）. Pearson correlation analysis showed that Hb and SF were negatively correlated with sST2（r=-0.167 8 and -0.291 4,P<0.05）,while hepcidin was positively correlated with sST2（r=0.353 3,P<0.05）. The results of ROC curve analysis showed that the areas under curves（AUC） of Hb,HCT,sST2,SF and hepcidin for the diagnosis of CHF combined with anemia were 0.640,0.531,0.734,0.789 and 0.845,respectively. The AUC of sST2 combined with SF and hepcidin for the diagnosis of CHF combined with anemia was 0.912. Conclusions sST2,SF and hepcidin are related to CHF combined with anemia,which may be applied as auxiliary diagnostic indexes.

Key words: Soluble suppression of tumorigenicity 2, Ferritin, Hepcidin, Chronic heart failure, Anemia