Role of serum carbohydrate antigen 153 determination in the disease course of megaloblastic anemia

doi:10.3969/j.issn.1673-8640.2019.12.011

Abstract

Abstract:

Objective To investigate the role of serum carbohydrate antigen 153（CA153） determination in the disease course of megaloblastic anemia（MA）. Methods A total of 48 MA patients without folic acid（FA） and vitamin B₁₂（VitB₁₂） supplement treatment were enrolled as research group,and 32 healthy subjects were enrolled as control group. The CA153 levels were determined in research group before and after treatment and control group. The correlations of CA153 with other determination indicators were evaluated. Results The level of CA153 in research group before treatment [（51.10±5.77）U/mL] was higher than that in control group [（20.22±4.69）U/mL]（P<0.001）. After FA and VitB₁₂ supplement treatment for 2-6 weeks,CA153 level in research group decreased [（21.92±4.52）U/mL]（P<0.001）,which had no statistical significance compared with that in control group（P=0.108）. CA153 was negatively correlated with hemoglobin（Hb）（r=-0.882,P<0.001）,and it was positively correlated with lactate dehydrogenase（LDH）（r=0.455,P=0.001）. Conclusions Serum CA153 levels increase in patients with MA. Serum CA153 determination can provide a reference for the early diagnosis of MA.

Key words: Carbohydrate antigen 153, Megaloblastic anemia, Folic acid, Vitamin B₁₂

CLC Number:

R446.1

YAN Kuanghua, ZHANG Tiansheng. Role of serum carbohydrate antigen 153 determination in the disease course of megaloblastic anemia[J]. Laboratory Medicine, 2019, 34(12): 1111-1113.

Figures/Tables 2

References 6

[1]	张之南. 血液病诊断及疗效标准[M]. 3版. 北京:科学技术出版社,2007:12-17.
[2]	BOZKURT M,YUMRU A E,ARAL I.Evaluation of the importance of the serum levels of CA-125,CA15-3,CA19-9,carcinoembryonic antigen and alpha fetoprotein for distinguishing benign and malignant adnexal masses and contribution of different test combinations to diagnostic accuracy[J]. Eur J Gynaecol Oncol,2013,34(6):540-544.
[3]	NISHIMURA R,NAGAO K,MIYAYAMA H,et al.Elevated serum CA15-3 levels correlate with positive estrogen receptor and initial favorable outcome in patients who died from recurrent breast cancer[J]. Breast Cancer,2003,10(3):220-227.
[4]	DUFFY M J,SHERING S,SHERRY F,et al.CA153:a prognostic marker in breast cancer[J]. Int J Biol Markers,2000,15(4):330-333.
[5]	MOLINA R,AUGE J M,ESCUDERO J M,et al.Mucins CA125,CA19.9,CA15.3 and TAG-72.3 as tumor markers in patients with lung cancer:comparison with CYFRA21-1,CEA,SCC and NSE[J]. Tumor Biol,2008,29(6):371-380.
[6]	陈曲波,黄妩姣,黎翠翠,等. Array-ELISA法和ECLIA法测定六项肿瘤标志物的比较研究[J]. 检验医学,2012,27(1):4-7.

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