Abstract: Objective　To investigate the comparability of different detection system blood coagulation analyzers，in order to achieve the efficiency of quality control. Methods　With STA compact and CA-1500 blood coagulation analyzers，the quality control material and 100 comparison blood samples（concentration covered biology reference interval） were determined. The measured results were analyzed and compared according to American Clinical Laboratory Improvement Amendment 88（CLIA′88） allowable total error 1/2 comparison and correlation（r＞0.975） as judgment standard. The instrument comparability and correlation were observed. Results　When STA compact and CA-1500 blood coagulation analyzers measuring samples without icterus and lipaemia，the results of international normalized ratio（INR） and low-value fibrinogen（Fbg） were consistent. The relative deviation was within allowance range，and the correlation was good（r＞0.975）. The result of activated patial thromboplastin time（APTT） correlation was fair，but the relative deviation was not allowed. The results of INR，APTT and Fbg was inconsistent when the samples was icterus or（and） lipaemia，and the relative deviation was not allowed and the correlation was bad（r＜0.975）. Conclusions　The comparability，correlation and differences can be reflected by comparing the results of different detection system blood coagulation analyzers

Key words: Detection system, International normalized ratio, Activated patial thromboplastin time, Fibrinogen, Correlation