Correlation between serum Sema4D，fibrinogen-to-albumin ratio and prognosis in patients with acute myeloid leukemia

doi:10.3969/j.issn.1673-8640.2025.08.008

Abstract

Abstract:

Objective To investigate the correlation between serum semaphorin 4D（Sema4D），fibrinogen-to-albumin ratio（FAR） and prognosis in patients with acute myeloid leukemia（AML）. Methods Totally，120 AML patients from Qinhuangdao First Hospital from May 2018 to July 2020 were enrolled as AML group. They were classified into high-risk group，intermediate-risk group and low-risk group according to karyotypes，and into survival group and death group according to 3-year survival status. Another 80 patients with iron deficiency anemia（IDA） and 80 healthy subjects were enrolled as IDA group and healthy control group，respectively. The differences in serum Sema4D levels and FAR were compared among the groups. Spearman correlation analysis was used to evaluate the correlation of serum Sema4D，FAR and the prognosis of AML patients. Receiver operating characteristic（ROC） curve was used to evaluate the efficacy of serum Sema4D and FAR in predicting the prognosis of AML patients. The survival status of AML patients was evaluated by Kaplan-Meier survival curve. Results The levels of serum Sema4D and FAR in AML group，IDA group and healthy control group were decreased successively（P<0.05）. The levels of serum Sema4D and FAR in high-risk group，intermediate-risk group and low-risk group were decreased successively（P<0.05）. Serum Sema4D and FAR in AML patients were positively correlated with the risk degree（r=0.452 and 0.577，P<0.001）. The serum Sema4D level and FAR in survival group were lower than those in death group（P<0.05）. The combined determination of serum Sema4D and FAR had a higher area under curve（AUC）（0.824） in predicting the prognosis of AML patients than single determinations（0.649 and 0.724）（P<0.05）. The 3-year survival rate of patients with high expression of serum Sema4D and high FAR was lower than that of patients with low expression of serum Sema4D and low FAR（P<0.05）. Conclusions The levels of Sema4D and FAR in AML patients are increased. Patients with low expression of Sema4D and low FAR have a higher 3-year survival rate. The combined determination of serum Sema4D and FAR has a higher efficacy in predicting the prognosis of AML patients.

Key words: Semaphorin 4D, Fibrinogen-to-albumin ratio, Acute myeloid leukemia

CLC Number:

R446.1

GUO Yuanyuan, SONG Hui, ZHANG Lin. Correlation between serum Sema4D，fibrinogen-to-albumin ratio and prognosis in patients with acute myeloid leukemia[J]. Laboratory Medicine, 2025, 40(8): 769-774.

Figures/Tables 9

References 20

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组别	例数	年龄/岁	性别		Sema4D/（ng·mL^-1）	FAR
组别	例数	年龄/岁	男/例	女/例	Sema4D/（ng·mL^-1）	FAR
AML组	120	55.24±13.25	63	57	15.33±1.39^*#	0.082±0.014^*#
IDA组	80	53.73±13.05	43	37	7.91±0.82^*	0.047±0.013^*
健康对照组	80	53.19±12.76	45	35	5.25±0.52	0.033±0.012
统计值		0.672	0.273		2 517.480	355.468
P值		0.512	0.872		< 0.001	<0.001

组别	例数	年龄/岁	性别		Sema4D/（ng·mL^-1）	FAR
组别	例数	年龄/岁	男/例	女/例	Sema4D/（ng·mL^-1）	FAR
AML组	120	55.24±13.25	63	57	15.33±1.39^*#	0.082±0.014^*#
IDA组	80	53.73±13.05	43	37	7.91±0.82^*	0.047±0.013^*
健康对照组	80	53.19±12.76	45	35	5.25±0.52	0.033±0.012
统计值		0.672	0.273		2 517.480	355.468
P值		0.512	0.872		< 0.001	<0.001

组别	例数	Sema4D/（ng·mL^-1）	FAR
低危组	36	12.25±1.43	0.065±0.012
中危组	44	15.59±0.96^*	0.084±0.011^*
高危组	40	17.83±1.35^*#	0.094±0.013^*#
F值		190.792	56.727
P值		<0.001	<0.001

组别	例数	Sema4D/（ng·mL^-1）	FAR
低危组	36	12.25±1.43	0.065±0.012
中危组	44	15.59±0.96^*	0.084±0.011^*
高危组	40	17.83±1.35^*#	0.094±0.013^*#
F值		190.792	56.727
P值		<0.001	<0.001

组别	例数/例	Sema4D/（ng·mL^-1）	FAR
生存组	78	15.06±1.29	0.075±0.021
死亡组	42	15.84±1.48	0.094±0.018
t值		3.026	4.962
P值		0.003	<0.001