Abstract:

：Objective To report a case of near-tetraploidy acute myeloid leukemia（NT-AML）,and to analyze its clinical,morphological and cytogenetic characteristics. Methods A case of NT-AML was reported,and its morphology,immunophenotype,treatment and prognosis were evaluated. Morphological characteristics included blast size,irregularity of nuclear contours,cytoplasmic vacuoles,granules and dysplasia. Results This case described acute myeloid leukemia with a near-tetraploid karyotype. Immunophenotype of blasts was consistent with myeloid leukemia phenotype,without expressing lymphoid marker. Blasts were characterized by hyper-granule in cytoplasm,resembling abnormal promyelocytes. It was also showed myelodysplasia-related morphologic changes in myeloid lineages. Conclusions NT-AML occurs in elder males,which exhibits large blast size and is associated with myelodysplasia. It is typically associated with a poor treatment response,low complete remission and short survival. Near-tetraploid karyotype could be used as a sign of poor prognosis with low survival.

Key words: Acute myeloid leukemia, Near-tetraploidy karyotype, Morphological characteristic, Prognosis