Role of plasma leptin determination in nutritional status and bone mineral density in preschool children

doi:10.3969/j.issn.1673-8640.2024.03.011

Abstract

Abstract:

Objective To investigate the role of plasma leptin determination in nutritional status and bone mineral density in preschool children. Methods Totally，140 preschool children who underwent physical examination in Nanyang Second People's Hospital from February 2020 to February 2021 were enrolled. The height and weight were measured，and body mass index（BMI） was calculated. Serum triglyceride（TG），total cholesterol（TC），high-density lipoprotein cholesterol（HDL-C），low-density lipoprotein cholesterol（LDL-C），albumin（Alb），hemoglobin（Hb） and plasma leptin levels were determined，and bone mineral density was determined as well. According to BMI，all the 140 children were classified into lean group（29 cases），normal group（61 cases） and overweight group（50 cases）. According to bone mineral density，all the children were classified into normal bone mineral density group（95 cases） and low bone mineral density group（45 cases）. Pearson correlation analysis was used to evaluate the correlation among the indicators. The efficacy of leptin in differentiating nutritional status and bone mineral density in preschool children was evaluated by receiver operating characteristic（ROC） curve. Results Compared with lean group，leptin levels in normal and overweight groups were increased（P<0.05），and overweight group's leptin levels were higher than those of normal group（P<0.05）. Leptin was positively correlated with BMI，TG，TC，LDL-C，Hb and Alb（r values were 0.672，0.486，0.603，0.422，0.244 and 0.388，respectively，P<0.01）. There was a negative correlation with HDL-C（r=-0.260，P=0.002）. The area under curve（AUC） of leptin for differentiating lean，normal children and normal，overweight children were 0.842 and 0.865，respectively. Compared with normal bone mineral density group，TG，TC，LDL-C，Alb，Hb and leptin in low bone mineral density group were decreased（P<0.05），and HDL-C was increased（P<0.05）. Leptin was positively correlated with speed of sound（SOS） of preschool children（r=0.217，P=0.010）. The AUC of leptin for differentiating normal and low bone mineral densities was 0.634. Conclusions The level of leptin in preschool children has a certain relationship with nutritional status and bone mineral density，which can be used to evaluate the nutritional status and bone mineral density of children.

Key words: Preschool children, Leptin, Nutritional status, Bone mineral density, Correlation

CLC Number:

R446.1

DONG Mingying, TAO Bingtong, LI Enyao. Role of plasma leptin determination in nutritional status and bone mineral density in preschool children[J]. Laboratory Medicine, 2024, 39(3): 272-276.

Figures/Tables 5

References 21

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组别	例数	瘦素/（mg·L^-1）
性别
男性	72	4.19±1.35
女性	68	4.01±1.24
t值		0.787
P值		0.433
年龄
3~4岁	69	3.92±1.22
5~6岁	71	4.28±1.35
t值		1.637
P值		0.104

组别	例数	瘦素/（mg·L^-1）
性别
男性	72	4.19±1.35
女性	68	4.01±1.24
t值		0.787
P值		0.433
年龄
3~4岁	69	3.92±1.22
5~6岁	71	4.28±1.35
t值		1.637
P值		0.104

组别	例数	BMI/ （kg·m^-2）	TG/（mmol·L^-1）	TC/（mmol·L^-1）	HDL-C/（mmol·L^-1）	LDL-C/（mmol·L^-1）	Hb/ （g·L^-1）	Alb/ （g·L^-1）	瘦素/（mg·L^-1）
偏瘦组	29	13.31±0.91	0.65±0.13	2.99±0.44	1.63±0.33	1.35±0.26	111.74±5.37	37.51±5.29	2.96±0.40
正常组	61	15.92±1.06^*	0.86±0.25^*	3.71±0.69^*	1.40±0.28^*	1.63±0.38^*	123.05±8.22^*	43.67±5.68^*	3.75±0.62
超重组	50	18.27±1.00^*#	1.14±0.25^*#	4.66±0.82^*#	1.33±0.23^*	2.01±0.56^*#	120.33±8.81^*	44.09±5.46^*	5.21±1.43^*#
F值		224.510	43.743	55.939	12.072	23.022	23.251	15.246	57.260
P值		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

组别	例数	BMI/ （kg·m^-2）	TG/（mmol·L^-1）	TC/（mmol·L^-1）	HDL-C/（mmol·L^-1）	LDL-C/（mmol·L^-1）	Hb/ （g·L^-1）	Alb/ （g·L^-1）	瘦素/（mg·L^-1）
偏瘦组	29	13.31±0.91	0.65±0.13	2.99±0.44	1.63±0.33	1.35±0.26	111.74±5.37	37.51±5.29	2.96±0.40
正常组	61	15.92±1.06^*	0.86±0.25^*	3.71±0.69^*	1.40±0.28^*	1.63±0.38^*	123.05±8.22^*	43.67±5.68^*	3.75±0.62
超重组	50	18.27±1.00^*#	1.14±0.25^*#	4.66±0.82^*#	1.33±0.23^*	2.01±0.56^*#	120.33±8.81^*	44.09±5.46^*	5.21±1.43^*#
F值		224.510	43.743	55.939	12.072	23.022	23.251	15.246	57.260
P值		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

组别	例数	SOS值/（m·s^-1）	BMI/（kg·m^-2）	TC/（mmol·L^-1）	TG/（mmol·L^-1）
正常骨密度组	95	3 251.06±204.60	16.54±2.07	4.03±0.97	0.96±0.30
低骨密度组	45	3 129.53±210.47	15.55±1.95	3.63±0.82	0.82±0.25
t值		3.064	2.675	2.415	2.785
P值		0.003	0.008	0.017	0.006
组别	LDL-C/（mmol·L^-1）	HDL-C/（mmol·L^-1）	Hb/（g·L^-1）	Alb/（g·L^-1）	瘦素/（mg·L^-1）
正常骨密度组	1.77±0.51	1.39±0.30	121.46±9.09	43.38±5.87	4.33±1.45
低骨密度组	1.57±0.43	1.49±0.27	117.97±7.73	40.79±6.16	3.63±0.94
t值	2.286	2.027	2.219	2.401	2.478
P值	0.024	0.045	0.028	0.018	0.015