Abstract: Objective　To investigate the changes of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) in hypertension and coronary heart disease and the cardiac function early injury in patients with diabetes mellitus and without abnormal renal function， and observe the change of NT -proBNP in hypertension and coronary heart disease before and after treatment. Methods　The 206 patients with hypertension and coronary heart disease and 65 patients with diabetes mellitus were classified into Ⅰ-Ⅱ grade group and Ⅲ-Ⅳ grade group according to the New York Heart Association (NYHA) heart pathological grading，and 37 patients without hypertension, coronary heart disease and diabetes mellitus in the department of bone traumatology were enrolled as controls. The NT-proBNP concentrations were detected. A total of 37 patients with hypertension and coronary heart disease were selected and compared for NT-proBNP concentrations before and after the treatment. The relationship of treatment and prognosis with NT-proBNP was observed. Results　The NT-proBNP levels in hypertension and coronary heart disease group and diabetes mellitus group were higher than those in the control group (P<0.01). The NT-proBNP levels in hypertension and coronary heart disease NYHA Ⅰ-Ⅱ grade group were higher than those in diabetes mellitus NYHA Ⅰ-Ⅱ grade group (P<0.05)，but there was no statistical difference in the NT-proBNP levels between hypertension and coronary heart disease NYHA Ⅲ-Ⅳ grade group and diabetes mellitus NYHA Ⅲ-Ⅳ grade group (P>0.05). The NT-proBNP levels in hypertension and coronary heart disease group after the treatment were significantly lower than those before the treatment (P<0.01). Conclusions　NT-proBNP can be used for the laboratory diagnosis of hypertension and coronary heart disease in cardiac function early injury, and associates with treatment and prognosis. NT-proBNP can reflect the change of cardiac function sensitively in the early development of diabetes mellitus.

Key words: N-terminal pro-B-type natriuretic peptide, Hypertension, Coronary heart disease, Diabetes mellitus