Relationship between plasma omentin-1 level and metabolic clearance rate in type 2 diabetes mellitus patients

doi:10.3969/j.issn.1673-8640.2022.01.005

Abstract

Abstract:

Objective To investigate the relationship between plasma omentin-1 level and metabolic clearance rate（MCR） in type 2 diabetes mellitus（T2DM）patients. Methods Totally,126 patients with T2DM and 102 healthy subjects were enrolled. The levels of plasma omentin-1,fasting blood glucose,glycated hemoglobin A_1c（HbA_1c）,total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C） were determined. MCR and homeostasis model assessment for insulin resistance（HOMR-IR） were calculated. According to MCR,126 patients were classified into high MCR group and low MCR group. Pearson correlation analysis was used. Multivariate stepwise regression analysis was used to analyze the influencing factors of MCR and HOMA-IR. Results The plasma omentin-1 and MCR levels in T2DM group were lower than those in healthy control group（P<0.01）. Compared with high MCR group,the levels of TC,TG,LDL-C,HbA_1c and HOMA-IR were higher,and the levels of HDL-C and plasma omentin-1 were lower in low MCR group（P<0.001）. Pearson correlation analysis showed that there were positive correlations between plasma omentin-1 and MCR,HDL-C（r=0.589 and 0.236,respectively,P<0.05）,and there were negative correlations between MCR and HbA_1c,TC,TG（r=-0.689,-0.120 and -0.420,respectively,P<0.05）. There was a negative correlation between HOMA-IR and plasma omentin-1（r=-0.752,P<0.001） and a positive correlation between HOMA-IR and TG（r=0.265,P<0.05）. The results of multivariate stepwise regression analysis showed that the main variables affecting MCR were HbA_1c and plasma omentin-1,and the main variable affecting HOMA-IR was plasma omentin-1. Conclusions There is a positive correlation between plasma omentin-1 and MCR in T2DM patients,which could be used as indicators to reflect the level of glycolipid metabolism.

Key words: Omentin-1, Metabolic clearance rate, Insulin resistance, Glycated hemoglobin A_1c, Type 2 diabetes mellitus

CLC Number:

R446.1

QU Yuanqing, ZHAO Fan, YE Ailian, LI Lifeng, ZHAO Haitao, LI Huizhen, LIANG Zhuohui, LI Liang. Relationship between plasma omentin-1 level and metabolic clearance rate in type 2 diabetes mellitus patients[J]. Laboratory Medicine, 2022, 37(1): 28-31.

Figures/Tables 3

References 19

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组别	例数	网膜素1/（ng/mL）	MCR
T2DM组	126	237.49±51.26	6.54±1.02
正常对照组	102	289.69±52.89	7.23±1.35
t值		7.538	3.237
P值		<0.001	0.002

组别	例数	网膜素1/（ng/mL）	MCR
T2DM组	126	237.49±51.26	6.54±1.02
正常对照组	102	289.69±52.89	7.23±1.35
t值		7.538	3.237
P值		<0.001	0.002

组别	例数	TC/ （mmol/L）	TG/ （mmol/L）	HDL-C/（mmol/L）	LDL-C/（mmol/L）	HbA_lc/%	HOMA-IR	网膜素1/（ng/mL）
低MCR组	63	4.70±0.61	2.17±0.32	1.04±0.17	3.12±0.56	8.46±0.62	4.42±1.02	212.65±11.69
高MCR组	63	4.22±0.56	1.38±0.24	1.22±0.19	2.65±0.47	7.68±0.59	3.48±0.84	262.32±12.28
t值		4.601	15.676	5.604	5.108	7.234	5.646	23.253
P值		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

组别	例数	TC/ （mmol/L）	TG/ （mmol/L）	HDL-C/（mmol/L）	LDL-C/（mmol/L）	HbA_lc/%	HOMA-IR	网膜素1/（ng/mL）
低MCR组	63	4.70±0.61	2.17±0.32	1.04±0.17	3.12±0.56	8.46±0.62	4.42±1.02	212.65±11.69
高MCR组	63	4.22±0.56	1.38±0.24	1.22±0.19	2.65±0.47	7.68±0.59	3.48±0.84	262.32±12.28
t值		4.601	15.676	5.604	5.108	7.234	5.646	23.253
P值		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

项目	网膜素1	HbA_lc	TC	TG	HDL-C	LDL-C
MCR
r值	0.589	-0.689	-0.120	-0.420	0.236	-0.241
P值	<0.001	<0.001	0.032	<0.001	0.023	0.020
HOMA-IR
r值	-0.752	0.128	0.016	0.265	-0.112	0.065
P值	<0.001	0.136	0.857	0.018	0.159	0.614