Abstract:

Objective To investigate the relationship between serum 25-hydroxyvitamin D [25（OH）D] level and disease severity,hormone responsiveness in children with allergic rhinitis-asthma syndrome. Methods Totally,50 healthy subjects were enrolled as control group,and 150 patients were enrolled in allergic rhinitis group（50 cases）,asthma group（50 cases） and allergic rhinitis-asthma syndrome group（50 cases）. Lung function [forced vital capacity（FVC）,forced expiratory volume in one second（FEV1）,forced expiratory flow rate 25%-75%（FEF25%-75%） and peak expiratory flow（PEF）] and serum 25（OH）D were determined. The situation of disease control was evaluated by modified British medical research council（mMRC） score,score for allergic rhinitis（SFAR） and asthma control test（ACT） score. According to hormone usage doses,allergic rhinitis-asthma syndrome group was subclassified into low-dose hormone group,middle-dose hormone group and high-dose hormone group. Linear regression analysis was used to evaluate the influence of 25（OH）D level on lung function and disease control. Results The serum 25（OH）D levels of asthma group,allergic rhinitis group and allergic rhinitis-asthma syndrome group were lower than that in control group（P<0.01）,and the difference among asthma group,allergic rhinitis group and allergic rhinitis-asthma syndrome group had statistical significance（P<0.01）. There was statistical significance in serum 25（OH）D levels among low-dose hormone group,middle-dose hormone group and high-dose hormone group（P<0.01）. Linear regression analysis showed that 25（OH）D in children with allergic rhinitis-asthma syndrome influenced on FEV1,FVC,FEF25%-75%,PEF,ACT score,mMRC score and SFAR（P<0.01）. Conclusions Serum 25（OH）D level is related to lung function and disease control in children with allergic rhinitis-asthma syndrome.

Key words: 25-Hydroxyvitamin D, Allergic rhinitis-asthma syndrome, Children