Abstract:

Objective To analyze the relationship between serum 25-hydroxyvitamin D [25（OH）D] level and gender，age，season，and to study the nutritional status of vitamin D in a physical examination population，so as to provide a reference for clinical rational vitamin D supplementation. Methods General data and laboratory determination results were collected from 23 438 patients who underwent physical examination in Peking University First Hospital from April 2019 to December 2023. The proportions of vitamin D sufficiency，insufficiency and deficiency and the relationship between serum 25（OH）D level and gender，age and season were compared under different evaluation criteria. Results The overall serum 25（OH）D level in the 23 438 patients was 48.89（38.43，63.07）nmol·L^-1. The proportions of vitamin D deficiency and insufficiency were high，and the proportion of vitamin D sufficiency was low. According to evaluation criterion A，the proportions of vitamin D deficiency，insufficiency and sufficiency were 7.80%，44.54% and 47.66%，respectively. According to evaluation criterion B，the proportions of vitamin D deficiency，insufficiency and sufficiency were 52.34%，34.42% and 13.24%，respectively. The serum 25（OH）D level in males was 53.57（42.92，67.30）nmol·L^-1，and the serum 25（OH）D level in females was 43.83（34.92，56.79）nmol·L^-1，and the difference in 25（OH）D level between different genders was statistically significant（P<0.001）. The serum 25（OH）D levels of the age groups from low to high were <31 years old group（41.23 nmol·L^-1），31-40 years old group（47.25 nmol·L^-1），41-50 years old group（48.37 nmol·L^-1），51-60 years old group（53.72 nmol·L^-1），>80 years old group（54.76 nmol·L^-1），71-80 years old group（58.83 nmol·L^-1） and 61-70 years old group（59.45 nmol·L^-1）. There was statistical significance in serum 25（OH）D level between males and females aged above 80 years（P<0.05）. There was statistical significance in vitamin D nutritional ststus levels between different seasons（P<0.001）. Conclusions The levels of 25（OH）D are generally insufficient or deficient in the physical examination population. The level of 25（OH）D is related to genders，ages and seasons. Personalized vitamin D supplementation should be provided based on genders，ages and seasons.

Key words: 25-Hydroxyvitamin D, Physical examination population, Gender, Age, Season