Abstract:

Objective To investigate the changes of apolipoprotein E （apo E） and lipoprotein（a）[Lp（a）] in patients with coronary heart disease （CHD）,and to investigate the correlations of apo E and Lp（a） with CHD severity. Methods A total of 229 CHD patients diagnosed by coronary arteriongraphy were enrolled. They were classified into 3 groups,unstable angina pectoris （UAP） group（73 cases）,stable angina pectoris（SAP） group（40 cases） and acute myocardial infarction（AMI） group （116 cases）. Totally,102 healthy subjects were enrolled as healthy control group. Serum apo E and Lp（a）levels were determined. CHD patients were classified into New York Heart Association （NYHA）Ⅰ-Ⅳ according to NYHA cardiac functional classification. CHD risk factor assessment was performed by Logistic regression analysis. Results The levels of Lp（a） in UAP,SAP and AMI groups were higher than those in healthy control group （P<0.05）,and the level of apo E in UAP group was higher than that in healthy control group（P<0.05）. The levels of Lp（a） and apo E were increased along with the increasing of CHD severity according to NYHA cardiac functional classification. However,the levels of apo E had no statistical significance between NYHA Ⅰ and NYHA Ⅱ （P>0.05）,and the levels of Lp（a）showed no statistical significance between NYHA Ⅲ and NYHA Ⅳ （P>0.05）. There was statistical significance for Lp（a） and apo E among other NYHA classification （P<0.05）. Logistic regression analysis showed that apo E and Lp （a） were independent risk factors for CHD [for apo E,odds ratio （OR）= 10.780,95% confidence interval （CI） 1.437-80.830;for Lp （a）,OR=4.930,95% CI 1.699-14.280]. Conclusions Lipid metabolic disorders are commonly seen in CHD patients with the decline of cardiac function. The parameters of apo E and Lp （a） may play roles in the pathogenesis of CHD.

Key words: Apolipoprotein E, Lipoprotein（a）, Atherosclerosis, Coronary heart disease