Research progress in the separation of serum lipoprotein subfractions and lipoprotein（a）

doi:10.3969/j.issn.1673-8640.2021.010.019

Abstract

Abstract:

Cardiovascular disease （CVD）still persists as the leading cause of morbidity and mortality all over the world. Serum lipoproteins are highly heterogeneous lipoproteins,which are composed of the particles that have different sizes,compositions and functions. Thus,lipoprotein subfractions and lipoprotein（a）[Lp（a）] are considered as important CVD risk factors. The clinical significance of measuring lipoprotein subfractions and Lp（a） is greater than traditional low-density lipoprotein cholesterol（LDL-C） and high-density lipoprotein cholesterol（HDL-C）determinations. In clinical practice,accurate and standardized laboratory diagnosis is crucial for the management of dyslipidemia and CVD prevention. Unifying the classification of lipoprotein subfractions and achieving complete separation of Lp（a） in order to achieve good traceability of lipoprotein subfractions and Lp（a） is essential. This review will summarize and discuss the separation technology of lipoprotein subfractions and Lp（a）.

Key words: Serum lipoprotein, Subfraction, Lipoprotein（a）, Separation technology

CLC Number:

R446.1

ZOU Jihua, ZHANG Wei, SHEN Min, ZHANG Man, TU Minmin, WANG Huimin, ZHOU Houqing. Research progress in the separation of serum lipoprotein subfractions and lipoprotein（a）[J]. Laboratory Medicine, 2021, 36(10): 1078-1086.

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