Abstract:

Objective To investigate the relationship between atopic dermatitis and the levels of serum apolipoprotein（apo） A1,apo B and apo E. Methods Totally,230 AD patients and 100 healthy subjects without the history of allergic diseases were enrolled. The levels of apo A1,apo B,apo E,total immunoglobulin E（IgE） and allergen [specific immunoglobulin E（sIgE）] were determined. Logistic regression analysis was used to evaluate the relationship between all the items and AD risk. Results Serum apo A1 levels of females in AD group and healthy control group were higher than those of males（P<0.05）. Serum apo A1 level of females in AD group was higher than that in healthy control group（P<0.05）. Serum apo B level of males in AD group was lower than that in healthy control group（P<0.01）. There was no statistical significance for the ratio of males and females with positive sIgE and total IgE>200 kU/L（P>0.05）,and there was no statistical significance between the group ≤7 years old and the group >7 years old（P>0.05）. Serum apo A1,apo B and apo E were positively correlated（r=0.190 and 0.287,respectively,P<0.01）. Serum apo A1 and apo B were not correlated（r=0.030,P>0.05）. Serum apo A1,apo B and apo E were positively correlated with age（r=0.191,0.417 and 0.143,respectively,P<0.01）. Logistic regression analysis showed that apo A1 could enable AD happening easily [odds ratio（OR）=7.346,95% confidence interval（CI） 2.349-22.977],however,total IgE and sIgE had no correlation. After adjusting age and sex,apo B was not correlated with the risk of AD,while it can put total IgE>200 kU/L more in danger（OR=6.694,95%CI 1.739-25.762）. Serum apo E always had no correlation with the risk of AD,total IgE and sIgE regardless of age or sex adjustment. Conclusions Serum apo A1 may be a risk factor contributing to the risk of AD,which is independent from IgE mediating. As apo B is influenced by factors,like age and sex,whether it can contribute to the risk of AD is not clear. Serum apo E will not cause the risk of AD.

Key words: Apolipoprotein A1, Apolipoprotein B, Apolipoprotein E, Immunoglobulin E, Atopic dermatitis