Abstract:

Objective To analyze plasma coagulation factors and D-dimer（DD） in patients with gestational diabetes mellitus（GDM） and gestational hypertension during the 3rd trimester pregnancy. Methods A total of 108 healthy pregnant women,104 patients with GDM and 52 patients with gestational hypertension were enrolled. Prothrombin time（PT）,activated partial thromboplastin time（APTT）,fibrinogen（FIB） and DD were determined. Results Compared with healthy pregnant women,FIB increased,and PT and APTT decreased in GDM group（P<0.05）. FIB increased,and PT decreased in gestational hypertension group compared with healthy pregnant women（P<0.05）. However,APTT had decreasing tendency without statistical significance（P>0.05）. When excluding 1 patient with severe coagulation disorder,the other 51 patients with gestational hypertension showed decreased APTT compared with healthy pregnant women（P<0.05）. Compared with healthy pregnant women,GDM and gestational hypertension groups showed no statistical significance for DD（P>0.05）. However,there were 3 cases of oligoamnios,fetal distress and venous thrombosis and 1 case of hemolysis,elevated liver enzymes and low platelet（HELLP） syndrome showing remarkable DD increasing. Conclusions Patients with GDM and gestational hypertension trend to be hypercoagulable,and high-level DD is probably associated with adverse pregnancy outcomes.

Key words: Coagulation function, Pregnancy, Diabetes mellitus, Hypertension