Abstract: Objective　To compare 2 methods with ACL-TOP automatic coagulation analyzerfor the determination offibrinogen（Fib），to evaluate the correlation and accuracy of test results，and to provide the referencefor the clinical laboratory methods. Methods　Von Clauss method and PT-der method with ACL-TOP automatic coagulation analyzer were used to detect thefib levels of normal PT group and the oral anticoagulant group. A high-concentrationfib sample was diluted withfactor diluent. The specific dilution ratios were in turn 1∶8，2∶7，3∶6，4∶5，5∶4，6∶3，7∶2，8∶1 andformer times. The dilution ratio was as the abscissa，and thefib level was as vertical axis measured by the 2 methods，respectively. A simple linear regression was performed. Results　Thefib levels of the normal PT group or oral anticoagulant group by the 2 methods were different significantly（P=0.000）. The results offib by PT-der method were significantly higher than those by Von Clauss method. The linearity of the 2 methods showed that the linearity of Von Clauss method was almost perfect，which was superior to that of PT-der method. Conclusions　The results of PT-der method forfib determination are higher than those of Von Clauss method with statistical significance. Von Clauss method can reflect thefib levels. The Von Clauss method recommended by National Committeefor Clinical Laboratory Standards（NCCLS） should be as the conventional method of clinical measurement.Key words：fibrinogen；Von Clauss method；PT-der method；Linearity

Key words: fibrinogen, Von Clauss method, PT-der method, Linearity